Staurosporine and ent-staurosporine: The first total syntheses, prospects for a regioselective approach, and activity profiles Journal Article

  


Authors: Link, J. T.; Raghavan, S.; Gallant, M.; Danishefsky, S. J.; Chou, T. C.; Ballas, L. M.
Article Title: Staurosporine and ent-staurosporine: The first total syntheses, prospects for a regioselective approach, and activity profiles
Abstract: The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo-glycal by direct epoxidation. The second bond was assembled from an exo-glycal by intramolecular iodoglycosylation.
Journal Title: Journal of the American Chemical Society
Volume: 118
Issue: 12
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 1996-03-27
Start Page: 2825
End Page: 2842
Language: English
PROVIDER: scopus
DOI: 10.1021/ja952907g
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0000314933&partnerID=40&md5=26204aadd75d35d03e4c2cda03a36c13
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Ting-Chao Chou
    319 Chou
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