Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial Journal Article

Authors: Grant, S. C.; Kostakoglu, L.; Kris, M. G.; Yeh, S. D. J.; Larson, S. M.; Finn, R. D.; Oettgen, H. F.; Cheung, N. K. V.
Article Title: Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial
Abstract: The present study evaluated the ability of the anti-GD2 ganglioside monoclonal antibody 3F8 to target tumor sites in patients with small-cell lung cancer (SCLC). Of 12 patients entered into the trial, ten received intravenous 3F8 labeled with 2 or 10 mCi iodine-131. The first five patients had recurrent or progressive disease after chemotherapy. Subsequent patients were studied before starting chemotherapy. Radionuclide scans were performed on days 1, 2, and 3 post-infusion and once between day 5 and day 7, Four patients underwent single-photon emission tomography (SPET) imaging. Radionuclide scans demonstrated localization to all known sites of disease, other than small brain metastases in one patient, SPET/CT scan fusion images confirmed precise localization. No significant toxicity was observed. Mean serum half-life was 64.2 h. Analysis of specimens from one patient who died of unrelated causes 6 days post-infusion confirmed the scan results. The present study demonstrates that 3F8 targets SCLC sites in patients. Further studies of anti-GD2 antibodies with higher doses of antibody and radionuclide are warranted to evaluate their role in SCLC.
Keywords: adult; clinical article; aged; middle aged; computer assisted tomography; lung neoplasms; monoclonal antibody; lung small cell cancer; iodine radioisotopes; pilot projects; radioisotope; drug half life; cancer scintiscanning; intravenous drug administration; small-cell lung cancer; carcinoma, small cell; photon emission tomography; tomography, emission-computed, single-photon; gangliosides; ganglioside; 3f8; radioimmunodetection; ganglioside antibody; lung scintiscanning; humans; human; male; female; article
Journal Title: European Journal of Nuclear Medicine
Volume: 23
Issue: 2
ISSN: 0340-6997
Publisher: Springer Verlag  
Date Published: 1996-02-01
Start Page: 145
End Page: 149
Language: English
DOI: 10.1007/bf01731837
PUBMED: 8925848
PROVIDER: scopus
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Samuel D J Yeh
    69 Yeh
  2. Nai-Kong Cheung
    471 Cheung
  3. Stefan C Grant
    26 Grant
  4. Ronald D Finn
    269 Finn
  5. Steven M Larson
    817 Larson
  6. Mark Kris
    647 Kris
  7. Herbert F Oettgen
    15 Oettgen