Future cancer research priorities in the USA: A Lancet Oncology Commission Journal Article


Authors: Jaffee, E. M.; Dang, C. V.; Agus, D. B.; Alexander, B. M.; Anderson, K. C.; Ashworth, A.; Barker, A. D.; Bastani, R.; Bhatia, S.; Bluestone, J. A.; Brawley, O.; Butte, A. J.; Coit, D. G.; Davidson, N. E.; Davis, M.; DePinho, R. A.; Diasio, R. B.; Draetta, G.; Frazier, A. L.; Futreal, A.; Gambhir, S. S.; Ganz, P. A.; Garraway, L.; Gerson, S.; Gupta, S.; Heath, J.; Hoffman, R. I.; Hudis, C.; Hughes-Halbert, C.; Ibrahim, R.; Jadvar, H.; Kavanagh, B.; Kittles, R.; Le, Q. T.; Lippman, S. M.; Mankoff, D.; Mardis, E. R.; Mayer, D. K.; McMasters, K.; Meropol, N. J.; Mitchell, B.; Naredi, P.; Ornish, D.; Pawlik, T. M.; Peppercorn, J.; Pomper, M. G.; Raghavan, D.; Ritchie, C.; Schwarz, S. W.; Sullivan, R.; Wahl, R.; Wolchok, J. D.; Wong, S. L.; Yung, A.
Article Title: Future cancer research priorities in the USA: A Lancet Oncology Commission
Abstract: We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$ 2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. Those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer. The US National Cancer Institute is already implementing some of those recommendations. As experts in the priority areas identified by the BRP, we bolster those recommendations to implement this important scientific roadmap. In this Commission, we examine the BRP recommendations in greater detail and expand the discussion to include additional priority areas, including surgical oncology, radiation oncology, imaging, health systems and health disparities, regulation and financing, population science, and oncopolicy. We prioritise areas of research in the USA that we believe would accelerate efforts to benefit patients with cancer. Finally, we hope the recommendations in this report will facilitate new international collaborations to further enhance global efforts in cancer control.
Keywords: neuropathy; positron-emission-tomography; randomized controlled-trial; cell lung-cancer; acute lymphoblastic-leukemia; metastatic breast-cancer; circulating tumor-cells; body radiation-therapy; targeted radionuclide therapy; induced peripheral; life-style changes
Journal Title: Lancet Oncology
Volume: 18
Issue: 11
ISSN: 1470-2045
Publisher: Elsevier Science, Inc.  
Date Published: 2017-11-01
Start Page: e653
End Page: e706
Language: English
ACCESSION: WOS:000414134100033
PROVIDER: wos
PUBMED: 29208398
DOI: 10.1016/S1470-2045(17)30698-8
Notes: Review -- Source: Wos
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MSK Authors
  1. Clifford Hudis
    838 Hudis
  2. Jedd D Wolchok
    637 Wolchok
  3. Daniel Coit
    415 Coit