Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12 372 individuals 10-49 years old: A population-based study from the National Health and Nutrition Examination Survey Journal Article


Authors: Landgren, O.; Graubard, B. I.; Kumar, S.; Kyle, R. A.; Katzmann, J. A.; Murata, K.; Costello, R.; Dispenzieri, A.; Caporaso, N.; Mailankody, S.; Korde, N.; Hultcrantz, M.; Therneau, T. M.; Larson, D. R.; Cerhan, J. R.; Rajkumar, S. V.
Article Title: Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12 372 individuals 10-49 years old: A population-based study from the National Health and Nutrition Examination Survey
Abstract: We studied the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in younger individuals, age 10-49 years, using samples from the National Health and Nutritional Examination Survey (NHANES) III. NHANES prevalence rates were standardized to the 2000 US total population. Among 12 372 individuals (4073 blacks, 4146 Mexican-Americans, 3595 whites, and 558 others), MGUS was identified in 63 persons (0.34%, 95% CI 0.23-0.50). The prevalence of MGUS was significantly higher in blacks (0.88%, 95% CI 0.62-1.26) compared with whites (0.22%, 95% CI 0.11-0.45), P = 0.001. The prevalence of MGUS in Mexican-Americans was at an intermediate level (0.41%, 95% CI 0.23-0.73). The disparity in prevalence of MGUS between blacks and whites was most striking in the 40-49 age-group; 3.26% (95% CI 2.04-5.18) versus 0.53% (95% CI 0.20-1.37), P = 0.0013. There was a trend to earlier age of onset of MGUS in blacks compared with whites. MGUS was seen in only two persons in the 10-19 age-group (both Mexican-American), and in three persons in the 20-29-year age-group (all of whom were black). In persons less than 50 years of age, MGUS is significantly more prevalent, with up to 10 years earlier age of onset, in blacks compared with whites.
Keywords: risk; american; multiple-myeloma; racial disparities; whites; socioeconomic-status; blacks; cancer; significance mgus; anthropometric characteristics
Journal Title: Blood Cancer Journal
Volume: 7
ISSN: 2044-5385
Publisher: Nature Publishing Group  
Date Published: 2017-10-20
Start Page: e618
Language: English
ACCESSION: WOS:000413469800002
DOI: 10.1038/bcj.2017.97
PROVIDER: wos
PMCID: PMC5678222
PUBMED: 29053158
Notes: Article -- Source: Wos
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MSK Authors
  1. Kazunori Murata
    12 Murata
  2. Carl Ola Landgren
    188 Landgren
  3. Neha Sanat Korde
    62 Korde