Neural lineage tracing in the mammalian brain Journal Article
| Authors: | Ma, J.; Shen, Z.; Yu, Y. C.; Shi, S. H. |
| Article Title: | Neural lineage tracing in the mammalian brain |
| Abstract: | Delineating the lineage of neural cells that captures the progressive steps in their specification is fundamental to understanding brain development, organization, and function. Since the earliest days of embryology, lineage questions have been addressed with methods of increasing specificity, capacity, and resolution. Yet, a full realization of individual cell lineages remains challenging for complex systems. A recent explosion of technical advances in genome-editing and single-cell sequencing has enabled lineage analysis in an unprecedented scale, speed, and depth across different species. In this review, we discuss the application of available as well as future genetic labeling techniques for tracking neural lineages in vivo in the mammalian nervous system. © 2017 Elsevier Ltd |
| Keywords: | unclassified drug; somatic mutation; review; nonhuman; cell lineage; genetic transfection; mammal; plasmid; retrovirus infection; cell labeling; brain nerve cell; neuroanatomical tract tracing; human; priority journal; crispr associated protein; clustered regularly interspaced short palindromic repeat; gene editing; crispr-cas9 system; protein cas9 |
| Journal Title: | Current Opinion in Neurobiology |
| Volume: | 50 |
| ISSN: | 0959-4388 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-06-01 |
| Start Page: | 7 |
| End Page: | 16 |
| Language: | English |
| DOI: | 10.1016/j.conb.2017.10.013 |
| PROVIDER: | scopus |
| PUBMED: | 29125960 |
| PMCID: | PMC5938148 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 December 2017 -- Source: Scopus |
