Advances in the management of HER2-positive early breast cancer Journal Article
| Authors: | Baselga, J.; Coleman, R. E.; Cortés, J.; Janni, W. |
| Article Title: | Advances in the management of HER2-positive early breast cancer |
| Abstract: | While trastuzumab is firmly established as the cornerstone of therapy for both early and advanced breast cancer expressing human epidermal growth factor receptor 2 (HER2), many patients either do not respond to trastuzumab treatment or progress following therapy. Improved understanding of breast cancer biology, particularly the complex signaling interactions managed by the HER family of receptors, have resulted in development of several novel HER2-directed therapies and combinations. This article will review the novel approaches to HER2 targeting that have been developed in recent years, with particular focus on results from these approaches in early breast cancer, and will discuss strategies to improve the tolerability of HER2-directed therapies, including prevention of cardiac toxicity and diarrhea. © 2017 Elsevier B.V. |
| Keywords: | cancer chemotherapy; event free survival; gene mutation; overall survival; review; fluorouracil; placebo; diarrhea; drug efficacy; monotherapy; nonhuman; treatment duration; drug targeting; capecitabine; paclitaxel; adjuvant therapy; disease free survival; neoadjuvant therapy; progression free survival; breast cancer; heart disease; epidermal growth factor receptor 2; aromatase inhibitor; cyclophosphamide; cancer resistance; docetaxel; temsirolimus; cancer hormone therapy; drug dose escalation; cardiotoxicity; epirubicin; dimerization; loperamide; octreotide; taxane derivative; anthracycline derivative; estrogen receptor; trastuzumab; metastatic breast cancer; lapatinib; her2; fulvestrant; neratinib; pertuzumab; budesonide; trastuzumab emtansine; atropine plus diphenoxylate; t-dm1; human epidermal growth factor receptor 2 positive breast cancer; human; solid malignant neoplasm; colestipol |
| Journal Title: | Critical Reviews in Oncology/Hematology |
| Volume: | 119 |
| ISSN: | 1040-8428 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2017-11-01 |
| Start Page: | 113 |
| End Page: | 122 |
| Language: | English |
| DOI: | 10.1016/j.critrevonc.2017.10.001 |
| PROVIDER: | scopus |
| PMCID: | PMC5662944 |
| PUBMED: | 29042085 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 December 2017 -- Source: Scopus |
