Advances in the treatment of gastric cancer Journal Article


Author: Ilson, D. H.
Article Title: Advances in the treatment of gastric cancer
Abstract: Purpose of review To review recent studies in esophagogastric cancer. Recent findings Positive emission tomography (PET) scan in follow-up after curative treatment of esophagogastric cancer did not lead to improved survival. In the preoperative treatment of esophagogastric cancer, the addition of the antivascular endothelial growth factor agent bevacizumab to perioperative chemotherapy with combination epirubicin, cisplatinum, and 5-fluorouracil (5-FU; ECF) failed to improve survival compared with chemotherapy alone. In a head-to-head comparison of preoperative chemotherapy for locally advanced gastric and esophagogastric adenocarcinoma, FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) significantly improved overall survival compared with ECF. Assessing response to induction chemotherapy prior to combined preoperative chemoradiotherapy in PET nonresponding patients allowed a change in chemotherapy during subsequent radiotherapy with improved rates of pathologic complete response. In human epidermal growth factor receptor-2-positive advanced esophagogastric adenocarcinoma, second-line treatment with the chemotherapy/trastuzumab drug conjugate emtansine/trastuzumab failed to improve response or overall survival compared with treatment using paclitaxel chemotherapy. The immune checkpoint inhibitor, nivolumab, improved survival in refractory gastric cancer. Summary Recent studies in gastric cancer clarify the optimal preoperative chemotherapy regimen and the use of PET scan as a response measure of preoperative therapy in esophagogastric cancer, and the role of targeted agents and immune checkpoint inhibitors in metastatic disease. © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: gastroesophageal cancer; esophagogastric cancer; flot
Journal Title: Current Opinion in Gastroenterology
Volume: 33
Issue: 6
ISSN: 0267-1379
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-11-01
Start Page: 473
End Page: 476
Language: English
DOI: 10.1097/mog.0000000000000395
PROVIDER: scopus
PUBMED: 28877045
DOI/URL:
Notes: Review -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. David H Ilson
    275 Ilson
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