An update in the nonendoscopic treatment of gastric cancer Journal Article

Author: Ilson, D. H.
Article Title: An update in the nonendoscopic treatment of gastric cancer
Abstract: Purpose of review This article reviews the recent seminal studies in esophagogastric cancer. Recent findings Regular low aspirin use may reduce the risk of esophagogastric cancer. Laparoscopic resection of locally advanced gastric cancer appears equivalent to open resection. There is no survival benefit for the addition of postoperative radiation therapy to adjuvant chemotherapy after primary gastric cancer resection. For tumors of the esophagus and gastroesophageal junction, the combination of preoperative radiation therapy with concurrent chemotherapy may be required to ensure achievement of a negative surgical margin and to reduce local tumor recurrence. Epirubicin may not add benefit to fluorinated pyrimidine and platinumbased chemotherapy, either in the preoperative setting or in the treatment of metastatic disease. The Her2-targeted agents lapatinib and trastuzumab emtansine failed to improve outcome when either added to or compared with chemotherapy. Immune checkpoint inhibition appears to be active in metastatic gastric cancer. Summary Recent studies in esophagogastric cancer help clarify the role of radiation therapy in surgical management, as well as the role of chemotherapeutic and targeted agents. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: laparoscopy; epirubicin; radiation therapy; gastric cancer; aspirin; immune checkpoint inhibitors
Journal Title: Current Opinion in Gastroenterology
Volume: 32
Issue: 6
ISSN: 0267-1379
Publisher: Lippincott Williams & Wilkins  
Date Published: 2016-11-01
Start Page: 501
End Page: 506
Language: English
DOI: 10.1097/mog.0000000000000314
PROVIDER: scopus
PUBMED: 27636304
PMCID: PMC5678974
Notes: Review -- Export Date: 6 December 2016 -- Source: Scopus
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MSK Authors
  1. David H Ilson
    275 Ilson
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