Cytologic assessment of estrogen receptor, progesterone receptor, and HER2 status in metastatic breast carcinoma Journal Article

   


Authors: Pareja, F.; Murray, M. P.; Des Jean, R.; Konno, F.; Friedlander, M.; Lin, O.; Edelweiss, M.
Article Title: Cytologic assessment of estrogen receptor, progesterone receptor, and HER2 status in metastatic breast carcinoma
Abstract: Introduction Discordance in the receptor status between primary breast carcinomas (PBCs) and corresponding metastasis is well documented. Interrogation of the receptor status of metastatic breast carcinoma (MBC) in cytology material is common practice, although its utility has not been thoroughly validated. We studied patients with MBC, and evaluated the concordance rates of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) between PBC surgical specimens and corresponding MBC cell blocks (CBs). We correlated the findings with clinicopathologic variables and with the fixation methods used. Materials and methods We searched for patients with MBC diagnosed on cytology from 2007 to 2009 and selected those with ER, PR, and HER2 tested in both the PBC surgical specimens and the MBC CBs. We included CBs fixed in formalin and methanol based solution (CytoLyt, Cytyc Corp., Boxborough, MA). All slides were reevaluated by cytopathologists. Clinical information was retrieved from the medical records. Results We studied 65 patients with PBC and MBC paired specimens. The concordance rates between PBC and MBC were 78.5%, 58.5% and 96.9%, for ER, PR and HER2, respectively. When discordant, PR status switched from positive (PBC) to negative (MBC) in most cases (23/27). The PR concordance rate was 45.2% for CBs fixed in formalin and 70.6% for those fixed with CytoLyt (P = 0.047). Conclusions The ER, PR, and HER2 concordance rates between the PBC and MBC CBs are similar to those reported in paired surgical specimens. PR status was the most prevalent discordance and was not accompanied by a switch in ER. © 2016 American Society of Cytopathology
Keywords: adult; controlled study; human tissue; aged; human cell; major clinical study; bone metastasis; lymph node metastasis; cytology; metastasis; breast cancer; epidermal growth factor receptor 2; cohort analysis; liver metastasis; lung metastasis; breast carcinoma; estrogen receptor; progesterone receptor; thorax wall; correlational study; her2; mediastinum metastasis; adrenal metastasis; soft tissue metastasis; pleura metastasis; fna; human; male; female; article; metastatic breast carcinoma; primary breast carcinoma
Journal Title: Journal of the American Society of Cytopathology
Volume: 6
Issue: 1
ISSN: 2213-2945
Publisher: American Society of Cytopathology  
Date Published: 2017-01-01
Start Page: 33
End Page: 40
Language: English
DOI: 10.1016/j.jasc.2016.10.001
PROVIDER: scopus
PMCID: PMC5436133
PUBMED: 28529880
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007049118&doi=10.1016%2fj.jasc.2016.10.001&partnerID=40&md5=22911d2847f02929425ce1661c2d5756
Notes: Article -- Export Date: 1 November 2017 -- Source: Scopus
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MSK Authors
  1. Melissa P Murray
    123 Murray
  2. Oscar Lin
    307 Lin
  3. Marcia Edelweiss
    104 Edelweiss
  4. Maria Friedlander
    43 Friedlander
  5. Fumiko Konno
    11 Konno
  6. Fresia Gilda Pareja Zea
    216 Pareja Zea
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