Indications for and complications of transfusion and the management of gynecologic malignancies Journal Article

   


Authors: Cybulska, P.; Goss, C.; Tew, W. P.; Parameswaran, R.; Sonoda, Y.
Article Title: Indications for and complications of transfusion and the management of gynecologic malignancies
Abstract: Anemia, which is highly prevalent in oncology patients, is one of the most established negative prognostic factors for several gynecologic malignancies. Multiple factors can cause or contribute to the development of anemia in patients with gynecologic cancers; these factors include blood loss (during surgery or directly from the tumor), renal impairment (caused by platinum-based chemotherapy), and marrow dysfunction (from metastases, chemotherapy, and/or radiation therapy). Several peri- and intra-operative strategies can be used to optimize patient management and minimize blood loss related to surgery. Blood transfusions are routinely employed as corrective measures against anemia; however, blood transfusions are one of the most overused healthcare interventions. There are safe and effective evidence-based blood transfusion strategies used in other patient populations that warrant further investigation in the surgical oncology setting. Blood is a valuable healthcare resource, and clinicians can learn to use it more judiciously through knowledge of the potential risks and complications of blood interventions, as well as the ability to properly identify the patients most likely to benefit from such interventions. © 2017 Elsevier Inc.
Keywords: antianemic agent; infection; neoplasm recurrence, local; anemia; genital neoplasms, female; hemodilution; tumor recurrence; iron; blood transfusion; immunomodulation; perioperative period; epidemiology; erythrocyte transfusion; blood loss, surgical; perioperative care; adverse effects; gynecologic malignancy; complication; hematinics; acute lung injury; procedures; tranexamic acid; antifibrinolytic agent; cancer; humans; human; female; antifibrinolytic agents; blood salvage; transfusion reaction; operative blood salvage
Journal Title: Gynecologic Oncology
Volume: 146
Issue: 2
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2017-08-01
Start Page: 416
End Page: 426
Language: English
DOI: 10.1016/j.ygyno.2017.05.010
PUBMED: 28528916
PROVIDER: scopus
PMCID: PMC5527999
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019347979&doi=10.1016%2fj.ygyno.2017.05.010&partnerID=40&md5=88b9d7526dd927ce8bf219b70d27c4ad
Notes: Review -- Corrigendum issued, see DOI: 10.1016/j.ygyno.2017.11.030 -- Export Date: 1 November 2017 -- Source: Scopus
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MSK Authors
  1. Yukio Sonoda
    472 Sonoda
  2. Rekha Parameswaran
    31 Parameswaran
  3. William P Tew
    244 Tew
  4. Cheryl Goss
    17 Goss
  5. Paulina Cybulska
    17 Cybulska
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