Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma Journal Article
| Authors: | Sait, S.; Pandit-Taskar, N.; Modak, S. |
| Article Title: | Failure of MIBG scan to detect metastases in SDHB-mutated pediatric metastatic pheochromocytoma |
| Abstract: | 123I-meta-iodo benzyl guanidine (MIBG) scans are considered the gold standard imaging in neuroblastoma; however, flouro deoxy glucose positron emission tomography (FDG-PET) scans have increased sensitivity in adults with pheochromocytoma/paraganglioma. We describe a pediatric patient initially considered to have localized neuroblastoma based on anatomical imaging and 123I-MIBG scan, but subsequent investigations revealed germline succinate dehydrogenase complex iron sulfur subunit B (SDHB) mutation–associated pheochromocytoma with multiple FDG-avid skeletal metastases. We then compared 123I-MIBG and FDG-PET scans in children with metastatic pheochromocytoma/paraganglioma. FDG-PET was superior to 123I-MIBG scan for the detection of skeletal metastases (median number of skeletal lesions detected 10 [range 1–30] vs. 2 [range 1–26], respectively; P = 0.005 by t-test). FDG-PET should be considered the functional scan of choice in children with pheochromocytoma/paraganglioma. © 2017 Wiley Periodicals, Inc. |
| Keywords: | solid tumor; imaging; metastatic pheochromocytoma |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 64 |
| Issue: | 11 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2017-11-01 |
| Start Page: | e26549 |
| Language: | English |
| DOI: | 10.1002/pbc.26549 |
| PROVIDER: | scopus |
| PUBMED: | 28409892 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 October 2017 -- Source: Scopus |
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250Modak -
343Pandit-Taskar -
66Farouk Sait
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