Alveolar soft part sarcoma of the bladder with ASPSCR1-TFE3 gene fusion as a secondary malignancy Journal Article
| Authors: | Rhee, D. S.; Dunkel, I. J.; Shukla, N. N.; Walsh, M. F.; Gilheeney, S. W.; Price, A. P.; Antonescu, C. R.; Heaton, T. E. |
| Article Title: | Alveolar soft part sarcoma of the bladder with ASPSCR1-TFE3 gene fusion as a secondary malignancy |
| Abstract: | Alveolar soft part sarcoma (ASPS) represents <1% of all soft tissue sarcomas and harbors the ASPSCR1-TFE3 translocation, which is found in pediatric renal cell carcinomas arising after chemotherapy. We present the case of a female patient, treated for metastatic retinoblastoma (Rb) with surgery, radiation, and chemotherapy at age 21 months, who was diagnosed with ASPS of the bladder 5 years later when imaging revealed a polypoid mass arising from the left bladder wall. Endoscopic biopsy and tumor resection were performed. After histopathologic confirmation of ASPSCR1-TFE3 fusion-positive ASPS, negative margins were achieved with wide local excision. At 18 months post-surgery, she remains recurrence-free. © 2017 The Authors |
| Keywords: | retinoblastoma; bladder tumor; alveolar soft part sarcoma; secondary malignancy; aspscr1-tfe3 translocation |
| Journal Title: | Journal of Pediatric Surgery Case Reports |
| Volume: | 27 |
| ISSN: | 2213-5766 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-12-01 |
| Start Page: | 19 |
| End Page: | 22 |
| Language: | English |
| DOI: | 10.1016/j.epsc.2017.09.007 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 October 2017 -- Source: Scopus |
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