Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient Journal Article


Authors: Jiménez-Sánchez, A.; Memon, D.; Pourpe, S.; Veeraraghavan, H.; Li, Y.; Vargas, H. A.; Gill, M. B.; Park, K. J.; Zivanovic, O.; Konner, J.; Ricca, J.; Zamarin, D.; Walther, T.; Aghajanian, C.; Wolchok, J. D.; Sala, E.; Merghoub, T.; Snyder, A.; Miller, M. L.
Article Title: Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient
Abstract: We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8+ and CD4+ T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8+ T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy. Video Abstract © 2017 The Authors
Keywords: genetics; mutation; case report; t lymphocyte; ovarian neoplasms; t-lymphocytes; pathology; tumor antigen; gene expression regulation; gene expression regulation, neoplastic; immunology; antigens, neoplasm; neoplasm metastasis; cystadenocarcinoma, serous; transcriptome; tumor microenvironment; humans; human; female
Journal Title: Cell
Volume: 170
Issue: 5
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2017-08-24
Start Page: 927
End Page: 938.e20
Language: English
DOI: 10.1016/j.cell.2017.07.025
PUBMED: 28841418
PROVIDER: scopus
PMCID: PMC5589211
DOI/URL:
Notes: Article -- Export Date: 2 October 2017 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Evis Sala
    95 Sala
  2. Jedd D Wolchok
    665 Wolchok
  3. Taha Merghoub
    206 Merghoub
  4. Jason Konner
    85 Konner
  5. Dmitriy Zamarin
    56 Zamarin
  6. Oliver Zivanovic
    118 Zivanovic
  7. Kay Jung Park
    182 Park
  8. Yanyun Li
    22 Li
  9. Jacob M Ricca
    14 Ricca
  10. Stephane Pourpe
    3 Pourpe