Synapse - Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient

Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient Journal Article

Authors:	Jiménez-Sánchez, A.; Memon, D.; Pourpe, S.; Veeraraghavan, H.; Li, Y.; Vargas, H. A.; Gill, M. B.; Park, K. J.; Zivanovic, O.; Konner, J.; Ricca, J.; Zamarin, D.; Walther, T.; Aghajanian, C.; Wolchok, J. D.; Sala, E.; Merghoub, T.; Snyder, A.; Miller, M. L.
Article Title:	Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient
Abstract:	We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8+ and CD4+ T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8+ T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy. Video Abstract © 2017 The Authors
Keywords:	genetics; mutation; case report; t lymphocyte; ovarian neoplasms; t-lymphocytes; pathology; tumor antigen; gene expression regulation; gene expression regulation, neoplastic; immunology; antigens, neoplasm; neoplasm metastasis; cystadenocarcinoma, serous; transcriptome; tumor microenvironment; humans; human; female
Journal Title:	Cell
Volume:	170
Issue:	5
ISSN:	0092-8674
Publisher:	Cell Press
Date Published:	2017-08-24
Start Page:	927
End Page:	938.e20
Language:	English
DOI:	10.1016/j.cell.2017.07.025
PUBMED:	28841418
PROVIDER:	scopus
PMCID:	PMC5589211
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028377618&doi=10.1016%2fj.cell.2017.07.025&partnerID=40&md5=018635f40d2d193bc230d36ef34cd09c
Notes:	Article -- Export Date: 2 October 2017 -- Source: Scopus