Molecular chaperones and how addiction matters in cancer therapy Book Section

  


Authors: Guzman, M. L.; Lowery, M. A.; Taldone, T.; Koren, J. 3rd; DaGama, E. G.; Chiosis, G.
Editor: Johnson, D. E.
Article/Chapter Title: Molecular chaperones and how addiction matters in cancer therapy
Title Series: Cell Death in Biology and Diseases
Abstract: Constitutive expression of HSP90 in normal cells is required for its evolutionarily conserved housekeeping function of folding and translocating cellular proteins to their proper cellular compartment. Under the stress of malignant transformation, cellular proteins and networks become perturbed requiring specific maintenance by a stress-modified HSP90. We here detail the many functions this oncogenic HSP90 takes on in cancer cells and discuss how the addiction of cancer-altered networks on HSP90 can be harvested therapeutically by small mol- ecule HSP90 inhibitors. © Springer Science+Business Media New York 2013. All rights reserved.
Book Title: Cell Death Signaling in Cancer Biology and Treatment
ISBN: 978-1-4614-5846-3
Publisher: Humana Press Inc  
Publication Place: New York, NY
Date Published: 2013-01-01
Start Page: 181
End Page: 203
Language: English
DOI: 10.1007/978-1-4614-5847-0_7
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028854844&doi=10.1007%2f978-1-4614-5847-0_7&partnerID=40&md5=f3a590c8d8c5ab11f9716a3585929c81
Notes: Book Chapter: 7 -- Export Date: 2 October 2017 -- Source: Scopus
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MSK Authors
  1. Maeve Aine Lowery
    133 Lowery
  2. Erica M. Gomes-Dagama
    15 Gomes-Dagama
  3. Gabriela Chiosis
    279 Chiosis
  4. Tony Taldone
    93 Taldone
  5. John Koren
    13 Koren
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