Proteomic interrogation of HSP90 and insights for medical research Journal Article

Authors: Weidenauer, L.; Wang, T.; Joshi, S.; Chiosis, G.; Quadroni, M. R.
Article Title: Proteomic interrogation of HSP90 and insights for medical research
Abstract: Introduction: Heat shock protein 90 (HSP90) regulates protein homeostasis in eukaryotes. As a ‘professional interactor’, HSP90 binds to and chaperones many proteins and has both housekeeping and disease-related functions but its regulation remains in part elusive. HSP90 complexes are a target for therapy, notably against cancer, and several inhibitors are currently in clinical trials. Proteomic studies have revealed the vast interaction network of HSP90 and, in doing so, the extent of cellular processes the chaperone takes part in, especially in yeast and human cells. Furthermore, small-molecule inhibitors were used to probe the global impact of its inhibition on the proteome. Areas covered: We review here recent HSP90-related interactomics and total proteome studies and their relevance for research on cancer, neurodegenerative and pathogen diseases. Expert commentary: Proteomics experiments are our best chance to identify the context-dependent global proteome of HSP90 and thus uncover and understand its disease-specific biology. However, understanding the complexity of HSP90 will require multiple complementary, quantitative approaches and novel bioinformatics to translate interactions into ordered functional networks and pathways. Developing therapies will necessitate more knowledge on HSP90 complexes and networks with disease relevance and on total proteome changes induced by their perturbation. Most work has been done in cancer, thus a lot remains to be done in the context of other diseases. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: review; nonhuman; proteome; protein protein interaction; proteomics; medical research; heat shock protein 90 inhibitor; heat shock protein 90; degenerative disease; protein immobilization; human disease; chaperones; cancer; human; epichaperome; malignant neoplasm; chaperome; hsp90 interactome; hsp90 networks; infectious agent
Journal Title: Expert Review of Proteomics
Volume: 14
Issue: 12
ISSN: 1478-9450
Publisher: Informa Healthcare  
Date Published: 2017-01-01
Start Page: 1105
End Page: 1117
Language: English
DOI: 10.1080/14789450.2017.1389649
PROVIDER: scopus
PUBMED: 28990809
PMCID: PMC6027630
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Gabriela Chiosis
    220 Chiosis
  2. Tai   Wang
    7 Wang
  3. Suhasini Joshi
    3 Joshi