A stratified myeloid system, the challenge of understanding macrophage diversity Journal Article
| Authors: | Geissmann, F.; Mass, E. |
| Article Title: | A stratified myeloid system, the challenge of understanding macrophage diversity |
| Abstract: | The present issue of 'Seminars in Immunology' addresses the topic of macrophage biology, 100 years after the death of Elie Metchnikoff (May 1845-July 1916). As foreseen by Metchnikoff, the roles of macrophages in the maintenance of homeostasis and immunity against pathogens have become a broad and active area of investigation. We now start to realize that the myeloid system includes a multiplicity of cell types with diverse developmental origins and functions. Therefore, the textbook picture of a plastic and multifunctional macrophage does not meet the requirements of our current knowledge anymore. Further development toward a quantitative and molecular understanding of myeloid cell biology in vivo and their roles in tissue homeostasis and remodeling will benefit from taking this complexity into account. A tentative model to help in this pursuit and account for myeloid cell and macrophage diversity is discussed below. © 2016. |
| Keywords: | cytology; dendritic cells; immune response; development; bone marrow cell; monocyte; macrophage; homeostasis; model; differentiation; tissue remodelling |
| Journal Title: | Seminars in Immunology |
| Volume: | 27 |
| Issue: | 6 |
| ISSN: | 1044-5323 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2015-12-01 |
| Start Page: | 353 |
| End Page: | 356 |
| Language: | English |
| DOI: | 10.1016/j.smim.2016.03.016 |
| PROVIDER: | scopus |
| PMCID: | PMC4968038 |
| PUBMED: | 27038773 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 September 2017 -- Source: Scopus |
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