Reexamining how cancer cells exploit the body's metabolic resources Conference Paper
| Authors: | Thompson, C. B.; Palm, W. |
| Title: | Reexamining how cancer cells exploit the body's metabolic resources |
| Conference Title: | 81st Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Targeting Cancer |
| Abstract: | A key feature of multicellular life is the sharing of nutritional resources by all cells of the organism. In animals, the allocation of nutrients to individual cells is not determined in a cell-autonomous fashion. Instead, growth factor and hormonal signaling pathways have evolved to regulate cellular nutrient uptake, which prevents individual cells from parasitizing the organism's metabolic reserves. Cancer is a condition where the highly ordered regulation of nutrient distribution is disrupted. During carcinogenesis, transformed cells acquire mutations in signaling pathways that render nutrient uptake cell-autonomous. A deeper understanding of how the acquisition of potential nutrients is regulated may help develop improved approaches to cancer therapy. © 2016 Thompson and Palm. |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 81 |
| Conference Dates: | 2016 Jun 1-5 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2016-01-01 |
| Start Page: | 67 |
| End Page: | 72 |
| Language: | English |
| DOI: | 10.1101/sqb.2016.81.030734 |
| PROVIDER: | scopus |
| PUBMED: | 28396524 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2017 -- Source: Scopus |
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