CAR T-cell therapy for pancreatic cancer Journal Article

   


Authors: DeSelm, C. J.; Tano, Z. E.; Varghese, A. M.; Adusumilli, P. S.
Article Title: CAR T-cell therapy for pancreatic cancer
Abstract: Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeting pancreatic cancer with CAR T-cell therapy. © 2017 Wiley Periodicals, Inc.
Keywords: immunotherapy; adoptive cell therapy; chimeric antigen receptor; checkpoint blockade; car t cells
Journal Title: Journal of Surgical Oncology
Volume: 116
Issue: 1
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2017-07-01
Start Page: 63
End Page: 74
Language: English
DOI: 10.1002/jso.24627
PROVIDER: scopus
PMCID: PMC5491361
PUBMED: 28346697
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016512352&doi=10.1002%2fjso.24627&partnerID=40&md5=0d1eccc3f7541502dbbeb9964f5b1b1a
Notes: Review -- Export Date: 1 August 2017 -- Source: Scopus
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MSK Authors
  1. Anna Mary Varghese
    145 Varghese
  2. Prasad S Adusumilli
    496 Adusumilli
  3. Carl J Deselm
    17 Deselm
  4. Zachary Tano
    11 Tano
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