Left-lateralization of resting state functional connectivity between the presupplementary motor area and primary language areas Journal Article
| Authors: | Lou, W.; Peck, K. K.; Brennan, N.; Mallela, A.; Holodny, A. |
| Article Title: | Left-lateralization of resting state functional connectivity between the presupplementary motor area and primary language areas |
| Abstract: | An abundance of evidence points to the role of a presupplementary motor area (pre-SMA) in human language. This study explores the pre-SMA resting state connectivity network and the nature of its connections to known language areas. We tested the hypothesis that by seeding the pre-SMA, one would be able to establish language laterality to known cortical and subcortical language areas. We analyzed data from 30 right-handed healthy controls and performed the resting state functional MRI. A seed-based analysis using a manually drawn pre-SMA region of interest template was applied. Time-course signals in the pre-SMA region of interest were averaged and cross-correlated to every voxel in the brain. Results show that the pre-SMA has significant left-lateralized functional connectivity to the pars opercularis within Broca's area. Among cortical regions, pre-SMA functional connectivity is strongest to the pars opercularis In addition, pre-SMA connectivity was shown to exist to other cortical language-association regions, including Wernicke's Area, supramarginal gyri, angular gyri, and middle frontal gyri. Among subcortical areas, considerable left-lateralized functional connectivity occurs to the caudate and thalamus, whereas cerebellar subregions show right lateralization. The current study shows that the pre-SMA most strongly connects to the pars opercularis within Broca's area and that cortical connections to language areas are left lateralized among a sample of right-handed patients. We provide resting state functional MRI evidence that the functional connectivity of the pre-SMA is involved in semantic language processing and that this identification may be useful for establishing language laterality in preoperative neurosurgical planning. © 2017 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | supplementary motor area; presupplementary motor area; functional connectivity; resting state network; resting state functional mri; language network |
| Journal Title: | NeuroReport |
| Volume: | 28 |
| Issue: | 10 |
| ISSN: | 0959-4965 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2017-07-05 |
| Start Page: | 545 |
| End Page: | 550 |
| Language: | English |
| DOI: | 10.1097/wnr.0000000000000783 |
| PROVIDER: | scopus |
| PMCID: | PMC5466468 |
| PUBMED: | 28538516 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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