Acquisition and storage of clinical samples to establish PDX models Book Section
| Authors: | Mattar, M.; Abdel-Wahab, O.; de Stanchina, E. |
| Editors: | Uthamanthil, R.; Tinkey, P.; de Stanchina, E. |
| Article/Chapter Title: | Acquisition and storage of clinical samples to establish PDX models |
| Abstract: | Obtaining and propagating patient-derived samples is a complex process that requires a high degree of coordination among a number of different services spanning from the clinic to the research side, and presents challenges that are administrative, procedural, and technical. Patients need to be selected according to specific criteria and consented to the correct institutional review board protocol; surgery and pathology personnel need to be alerted; samples must be retrieved and delivered to research personnel in a timely and organized manner; samples must be skillfully processed and implanted in mice or stored for subsequent analysis; and sample annotation and proper documentation of each step has to be maintained throughout the entire process. In this chapter, we will discuss the key aspects of this intricate process. © 2017 Elsevier Inc. All rights reserved. |
| Keywords: | engraftment; pdx; institutional review board; standard operating procedures; irb protocol; patient sample acquisition |
| Book Title: | Patient Derived Tumor Xenograft Models: Promise, Potential and Practice |
| ISBN: | 978-0-12-804010-2 |
| Publisher: | Academic Press, Elsevier Inc |
| Publication Place: | London, UK |
| Date Published: | 2017-01-01 |
| Start Page: | 109 |
| End Page: | 118 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-804010-2.00008-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Publisher-provided doi does not resolve (as of 12/12/2018) -- Book Section II Chapter 2 -- Export Date: 3 July 2017 -- Source: Scopus |
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