The role of p53 in chemosensitivity of gastric cancer Conference Paper
| Authors: | Kim, S. J.; Lee, C. G.; Chang, F.; Banerjee, D.; Karpeh, M. S. |
| Editors: | Siewert, J. R.; Roder, J. D. |
| Title: | The role of p53 in chemosensitivity of gastric cancer |
| Conference Title: | 2nd International Gastric Cancer Congress |
| Abstract: | Previous studies have shown that p53 and p53-dependent p21/WAF1 protein status may have an influence on chemosensitivity in gastric cancer. To delineate the role of p53 more directly, we established a number of cell lines expressing either wild- or mutant-type p53 from p53 null parental KATO III cell line. The doubling time of KATO III was markedly increased by wild- and mutant-type p53 as well. The p21/WAF1 expression was induced in both wild- and mutant-type p53 transfectants in a p53-dependent manner when cells reached confluence. Wild-type p53 transfectants exposed to a lethal dose of adriamycin also induced p21/WAF1. The comparative studies performed with KATO III and newly established cell lines indicated that loss of p53 gene correlated with the chemoresistance of KATO III and that the ectopic expression of functional p53 in KATO III renders cells more susceptible to adriamycin. |
| Journal Title | Progress in Gastric Cancer Research 1997: Proceedings of the 2nd International Gastric Cancer Congress |
| Conference Dates: | 1997 Apr 27-30 |
| Conference Location: | Munich, Germany |
| ISBN: | 9788832304275 |
| Publisher: | Monduzzi Editore |
| Location: | Bologna, Italy |
| Date Published: | 1997-01-01 |
| Start Page: | 1287 |
| End Page: | 1290 |
| Language: | English |
| ACCESSION: | WOS:A1997BJ02Q00243 |
| PROVIDER: | wos |
| Notes: | Proceedings Paper -- Source: Wos |
