Long-term results of lung metastasectomy: Prognostic analyses based on 5206 cases Journal Article
| Author: | The International Registry of Lung Metastases Writing Committee |
| Contributors: | Ginsberg, R. J.; McCormack, P. |
| Article Title: | Long-term results of lung metastasectomy: Prognostic analyses based on 5206 cases |
| Abstract: | Objectives: The International Registry of Lung Metastases was established in 1991 to assess the long-term results of pulmonary metastasectomy, Methods: The Registry has accrued 5206 cases of lung metastasectomy, from 18 departments of thoracic surgery in Europe (n = 13), the United States (n = 4) and Canada (n = 1), Of these patients, 4572 (88%) underwent complete surgical resection. The primary tumor was epithelial in 2260 cases, sarcoma in 2173, germ cell in 363, and melanoma in 328, The disease-free interval was 0 to 11 months in 2199 cases, 12 to 35 months in 1857, and more than 36 months in 1620, Single metastases accounted for 2383 cases and multiple lesions for 2726, Mean follow-up nas 46 months, Analysis was performed by Kaplan-Meier estimates of survival, relative risks of death, and multivariate Cox model, Results: The actuarial survival after complete metastasectomy was 36% at 5 years, 26% at 10 years, and 22% at 15 years (median 35 months); the corresponding values for incomplete resection were 13% at 5 years and 7% at 10 years (median 15 months), Among complete resections, the 5-year survival was 33% for patients with a disease-free interval of 0 to 11 months and 45% for those with a disease-free interval of more than 36 months; 43% for single lesions and 27% for four or more lesions. Multivariate analysis showed a better prognosis for patients with germ cell tumors, disease-free intervals of 36 months or more, and single metastases. Conclusions: These results confirm that lung metastasectomy is a safe and potentially curative procedure, Resectability, disease-free interval, and number of metastases enabled us to design a simple system of classification valid for different tumor types. |
| Keywords: | chemotherapy; tomography; surgery; resection; osteogenic-sarcoma; soft-tissue sarcomas; adjuvant; surgical-management; pulmonary metastases; median sternotomy |
| Journal Title: | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 113 |
| Issue: | 1 |
| ISSN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 1997-01-01 |
| Start Page: | 37 |
| End Page: | 49 |
| Language: | English |
| ACCESSION: | WOS:A1997WC26700005 |
| DOI: | 10.1016/s0022-5223(97)70397-0 |
| PROVIDER: | wos |
| PUBMED: | 9011700 |
| Notes: | Article; Proceedings Paper -- 76th Annual Meeting of the American-Association-for-Thoracic-Surgery -- APR 28-MAY 01, 1996 -- SAN DIEGO, CA -- Source: Wos |
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