Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir Journal Article
| Author: | Studies of Ocular Complications of AIDS (SOCA) in collaboration with the AIDS Clinical Trials Group |
| Contributors: | Heinemann, M. H.; Polsky, B.; Squires, K.; Wise-Campbell, S. |
| Article Title: | Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir |
| Abstract: | The objectives of the study were to examine the clinical significance of cytomegalovirus (CMV) culture results and drug susceptibilities in CMV isolates from patients with AIDS-related CMV retinitis, Blood and urine for CMV culture were obtained from 207 patients with newly diagnosed CMV retinitis who were enrolled in a randomized trial comparing foscarnet and ganciclovir. Culture-positive rates at baseline were 45% and 71% for blood and urine, respectively. Rates decreased 3- to 10-fold after initiation of either treatment. Mortality was related to both positive baseline blood and urine cultures; adjusted relative risks were 1.97 and 2.03, respectively, Positive blood cultures at baseline were associated with more rapid retinitis progression. Drug-resistant CMV was found, over comparable follow-up periods on assigned treatment, in 4 of 8 ganciclovir-assigned patients with persistent viremia and 0 of 5 foscarnet-assigned patients with persistent viremia, Results of virologic assays of blood appear to be associated with clinical outcome of CMV retinitis. |
| Keywords: | infection; disease; virus retinitis |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 176 |
| Issue: | 1 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1997-07-01 |
| Start Page: | 50 |
| End Page: | 58 |
| Language: | English |
| ACCESSION: | WOS:A1997XH27500007 |
| PROVIDER: | wos |
| PUBMED: | 9207349 |
| Notes: | Article -- Source: Wos |
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