Use of the ganciclovir implant for treating cytomegalovirus retinitis secondary to immunosuppression after bone marrow transplantation Journal Article


Authors: McAuliffe, P. F.; Hall, M. J.; Castro-Malaspina, H.; Heinemann, M. H.
Article Title: Use of the ganciclovir implant for treating cytomegalovirus retinitis secondary to immunosuppression after bone marrow transplantation
Abstract: PURPOSE: To report a case in which we treated cytomegalovirus retinitis using an intravitreal ganciclovir sustained-release device in a patient negative for the human immunodeficiency virus, with a history of myeloproliferative syndrome with myelofibrosis and profound immunosuppression after allogeneic bone marrow transplantation. METHODS: Case report. Review of medical records and fundus photographs. RESULTS: After the ganciclovir device was implanted, the cytomegalovirus retinitis did not progress, and visual acuity improved, We removed the device 9 months after implantation. CONCLUSIONS: The;ganciclovir sustained-release device may be useful for treating cytomegalovirus retinitis in patients without the acquired immunodeficiency syndrome who are profoundly immunosuppressed and fail conventional intravenous therapy, If immune suppression is of limited duration, the device can be removed.
Journal Title: American Journal of Ophthalmology
Volume: 123
Issue: 5
ISSN: 0002-9394
Publisher: Elsevier Science, Inc.  
Date Published: 1997-05-01
Start Page: 702
End Page: 703
Language: English
ACCESSION: WOS:A1997WX86900021
PROVIDER: wos
PUBMED: 9152083
Notes: Article -- Source: Wos
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