Conceptual basis for advances in the systemic drug therapy of breast cancer Journal Article
| Author: | Norton, L. |
| Article Title: | Conceptual basis for advances in the systemic drug therapy of breast cancer |
| Abstract: | Several directions are currently being explored to improve treatment outcome among patients with breast cancer. Although regulation of cell division likely will be necessary to effect an ultimate cure for cancer, work continues into maximizing responses to chemotherapy to manage the neoplastic progression and symptoms of disease. While new anticancer agents are being sought, progress has been most readily achieved through the concepts of drug dosing and scheduling. Manipulating treatment impact by altering drug intensity and using novel scheduling strategies are yielding improvement in responses, and newer concepts, such as the limits of cytoreduction, are gaining prominence in clinical trials. This article reviews the current knowledge, ongoing research protocols, and future directions in these areas of systemic therapy for breast cancer. |
| Keywords: | human tissue; treatment outcome; human cell; doxorubicin; fluorouracil; cancer growth; patient selection; treatment planning; antineoplastic agents; conference paper; paclitaxel; methotrexate; antineoplastic agent; cell division; breast cancer; drug administration schedule; cyclophosphamide; dose-response relationship, drug; breast neoplasms; cancer research; granulocyte colony-stimulating factor; theory; dose time effect relation; humans; human; female; priority journal |
| Journal Title: | Seminars in Oncology |
| Volume: | 24 |
| Issue: | 4 Suppl. 11 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-08-01 |
| Start Page: | S11-2 |
| End Page: | S11-12 |
| Language: | English |
| PUBMED: | 9314292 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 17 March 2017 -- Source: Scopus |
