Stereotactic radiosurgery for multiple brain metastases Conference Paper
| Authors: | Baldock, C.; Rozenfeld, A.; Metcalfe, P.; Lee, A.; Yamada, Y. |
| Title: | Stereotactic radiosurgery for multiple brain metastases |
| Conference Title: | Journal of Physics Conference Series |
| Abstract: | Whole brain radiation therapy has been the traditional treatment of choice for patients with multiple brain metastases. Although stereotactic radiosurgery is widely accepted for the management to up to 4 brain metastases, its use is still controversial in cases of 5 or more brain metastases. Randomized trials have suggested that stereotactic radiosurgery alone is appropriate in up to 4 metastases without concomitant whole brain radiation. Level 1 evidence also suggests that withholding whole brain radiation may also reduce the impact of radiation on neurocognitive function and also may even offer a survival advantage. A recent analysis of a large multicentre prospective database has suggested that there are no differences in outcomes such as the likelihood of new metastasis or leptomeningeal disease in cases of 2-10 brain metastases, nor in overall survival. Hence in the era of prolonged survival with stage IV cancer, stereotactic radiosurgery is a reasonable alternative to whole brain radiation in order to minimize the impact of treatment upon quality of life without sacrificing overall survival. |
| Keywords: | radiotherapy; trial; radiation-therapy; gamma-knife radiosurgery |
| Journal Title | Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy |
| Volume: | 777 |
| Issue: | 1 |
| Conference Dates: | 2016 Jan 26-28 |
| Conference Location: | Tasmania, Australia |
| ISBN: | 1742-6588 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2017-01-01 |
| Start Page: | 012031 |
| Language: | English |
| ACCESSION: | WOS:000399749800032 |
| PROVIDER: | wos |
| DOI: | 10.1088/1742-6596/777/1/012031 |
| Notes: | MMND&ITRO2016 -- Proceedings Paper -- Conference on Micro-Mini and Nano-Dosimetry and Innovative Technologies in Radiation Therapy (MMND and ITRO) -- JAN 26-28, 2016 -- Tasmania, AUSTRALIA -- DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND -- UNSP 012031 -- Source: Wos |
