Immune checkpoint inhibitors: An innovation in immunotherapy for the treatment and management of patients with cancer Journal Article


Authors: Dine, J.; Gordon, R.; Shames, Y.; Kasler, M. K.; Barton-Burke, M.
Article Title: Immune checkpoint inhibitors: An innovation in immunotherapy for the treatment and management of patients with cancer
Abstract: Cancer survival rates are generally increasing in the United States. These trends have been partially attributed to improvement in therapeutic strategies. Cancer immunotherapy is an example of one of the newer strategies used to fight cancer, which primes or activates the immune system to produce antitumor effects. The first half of this review paper concisely describes the cell mechanisms that control antitumor immunity and the major immunotherapeutic strategies developed to target these mechanisms. The second half of the review discusses in greater depth immune checkpoint inhibitors that have recently demonstrated tremendous promise for the treatment of diverse solid tumor types, including melanoma, non-small cell lung cancer, and others. More specifically, the mechanisms of action, side effects, and patient and family management and education concerns are discussed to provide oncology nurses up-to-date information relevant to caring for cancer-affected patients treated with immune checkpoint inhibitors. Future directions for cancer immunotherapy are considered.
Keywords: oncology nursing; cancer immunotherapy; oncology; dendritic cells; tumors; safety; therapy; trial; adverse events; endocrine; immune checkpoint inhibitor; nivolumab; anti-pd-1 antibody; symptom management
Journal Title: Asia-Pacific Journal of Oncology Nursing
Volume: 4
Issue: 2
ISSN: 2347-5625
Publisher: Medknow Publications  
Date Published: 2017-04-01
Start Page: 127
End Page: 135
Language: English
ACCESSION: WOS:000399662100010
DOI: 10.4103/apjon.apjon_4_17
PROVIDER: wos
PMCID: PMC5412150
PUBMED: 28503645
Notes: Review -- Source: Wos
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MSK Authors
  1. Ruth-Ann Roman
    27 Roman
  2. Yelena Shames
    6 Shames