Merkel cell carcinoma Journal Article


Author: Pulitzer, M.
Article Title: Merkel cell carcinoma
Abstract: Merkel cell carcinoma (MCC) encompasses neuroendocrine carcinomas primary to skin and occurs most commonly in association with clonally integrated Merkel cell polyomavirus with related retinoblastoma protein sequestration or in association with UV radiation–induced alterations involving the TP53 gene and mutations, heterozygous deletion, and hypermethylation of the Retinoblastoma gene. Molecular genetic signatures may provide therapeutic guidance. Morphologic features, although patterned, are associated with predictable diagnostic pitfalls, usually resolvable by immunohistochemistry. Therapeutic options for MCC, traditionally limited to surgical intervention and later chemotherapy and radiation, are growing, given promising early results of immunotherapeutic regimens. © 2017 Elsevier Inc.
Keywords: polyomavirus; neuroendocrine; merkel cell; uv
Journal Title: Surgical Pathology Clinics
Volume: 10
Issue: 2
ISSN: 1875-9181
Publisher: Elsevier Inc.  
Date Published: 2017-06-01
Start Page: 399
End Page: 408
Language: English
DOI: 10.1016/j.path.2017.01.013
PROVIDER: scopus
PMCID: PMC5443625
PUBMED: 28477888
DOI/URL:
Notes: Review -- Export Date: 2 June 2017 -- Source: Scopus
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MSK Authors
  1. Melissa P Pulitzer
    136 Pulitzer