Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer Journal Article
| Authors: | Stevanović, S.; Pasetto, A.; Helman, S. R.; Gartner, J. J.; Prickett, T. D.; Howie, B.; Robins, H. S.; Robbins, P. F.; Klebanoff, C. A.; Rosenberg, S. A.; Hinrichs, C. S. |
| Article Title: | Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer |
| Abstract: | Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor antigens targeted in successful treatments remain poorly defined.We used a personalized immunogenomic approach to elucidate the global landscape of antitumor T cell responses in complete regression of human papillomavirus-associated metastatic cervical cancer after tumor-infiltrating adoptive Tcell therapy. Remarkably, immunodominant Tcell reactivities were directed againstmutated neoantigens or a cancer germline antigen, rather than canonical viral antigens.Tcells targeting viral tumor antigens did not display preferential in vivo expansion. Both viral and nonviral tumor antigen-specificTcells resided predominantly in the programmed cell death 1 (PD-1)-expressing Tcell compartment, which suggests that PD-1 blockade may unleash diverse antitumor Tcell reactivities.These findings suggest a new paradigm of targeting nonviral antigens in immunotherapy of virally associated cancers. |
| Keywords: | unclassified drug; somatic mutation; cd8+ t lymphocyte; t lymphocyte; tumor associated leukocyte; cell compartmentalization; cancer immunotherapy; apoptosis; gene expression; in vivo study; tumor regression; cell population; tumor antigen; t lymphocyte receptor; antigen; antigen specificity; uterine cervix cancer; virus antigen; tumor; epithelium tumor; lymphocyte function; disease treatment; wart virus; immunization; human papillomavirus; immunogenetics; tumor immunogenicity; cells and cell components; cancer; human; priority journal; article; kita kyushu lung cancer antigen 1; metastatic cervical cancer; virus induced epithelial cancer |
| Journal Title: | Science |
| Volume: | 356 |
| Issue: | 6334 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2017-04-14 |
| Start Page: | 200 |
| End Page: | 205 |
| Language: | English |
| DOI: | 10.1126/science.aak9510 |
| PROVIDER: | scopus |
| PUBMED: | 28408606 |
| PMCID: | PMC6295311 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 June 2017 -- Source: Scopus |
