A comparison of pediatric and adult CT organ dose estimation methods Journal Article

   


Authors: Gao, Y.; Quinn, B.; Mahmood, U.; Long, D.; Erdi, Y.; St. Germain, J.; Pandit-Taskar, N.; Xu, X. G.; Bolch, W. E.; Dauer, L. T.
Article Title: A comparison of pediatric and adult CT organ dose estimation methods
Abstract: Background: Computed Tomography (CT) contributes up to 50% of the medical exposure to the United States population. Children are considered to be at higher risk of developing radiation-induced tumors due to the young age of exposure and increased tissue radiosensitivity. Organ dose estimation is essential for pediatric and adult patient cancer risk assessment. The objective of this study is to validate the VirtualDose software in comparison to currently available software and methods for pediatric and adult CT organ dose estimation. Methods: Five age groups of pediatric patients and adult patients were simulated by three organ dose estimators. Head, chest, abdomen-pelvis, and chest-abdomen-pelvis CT scans were simulated, and doses to organs both inside and outside the scan range were compared. For adults, VirtualDose was compared against ImPACT and CT-Expo. For pediatric patients, VirtualDose was compared to CT-Expo and compared to size-based methods from literature. Pediatric to adult effective dose ratios were also calculated with VirtualDose, and were compared with the ranges of effective dose ratios provided in ImPACT. Results: In-field organs see less than 60% difference in dose between dose estimators. For organs outside scan range or distributed organs, a five times' difference can occur. VirtualDose agrees with the size-based methods within 20% difference for the organs investigated. Between VirtualDose and ImPACT, the pediatric to adult ratios for effective dose are compared, and less than 21% difference is observed for chest scan while more than 40% difference is observed for head-neck scan and abdomen-pelvis scan. For pediatric patients, 2 cm scan range change can lead to a five times dose difference in partially scanned organs. Conclusions: VirtualDose is validated against CT-Expo and ImPACT with relatively small discrepancies in dose for organs inside scan range, while large discrepancies in dose are observed for organs outside scan range. Patient-specific organ dose estimation is possible using the size-based methods, and VirtualDose agrees with size-based method for the organs investigated. Careful range selection for CT protocols is necessary for organ dose optimization for pediatric and adult patients. © 2017 The Author(s).
Keywords: adult; child; clinical article; drug megadose; pelvis; low drug dose; computer assisted tomography; pediatric; simulation; abdomen; dosimetry; intermethod comparison; neck; software; monte carlo; head; effective dose; organ dose; thorax; human; ct dosimetry
Journal Title: BMC Medical Imaging
Volume: 17
Issue: 1
ISSN: 1471-2342
Publisher: Biomed Central Ltd  
Date Published: 2017-04-26
Start Page: 28
Language: English
DOI: 10.1186/s12880-017-0199-3
PROVIDER: scopus
PMCID: PMC5406971
PUBMED: 28446130
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018305213&doi=10.1186%2fs12880-017-0199-3&partnerID=40&md5=2003299479207c6d6485d69ccbbc5e54
Notes: Article -- Export Date: 2 June 2017 -- Source: Scopus
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MSK Authors
  1. Neeta Pandit-Taskar
    342 Pandit-Taskar
  2. Lawrence Dauer
    170 Dauer
  3. Yusuf E Erdi
    118 Erdi
  4. Jean M St Germain
    61 St Germain
  5. Brian Quinn
    20 Quinn
  6. Usman Ahmad Mahmood
    46 Mahmood
  7. Yiming Gao
    19 Gao
  8. Daniel Joseph Long
    6 Long
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