Radiation dosimetry of 18F-FDG PET/CT: Incorporating exam-specific parameters in dose estimates Journal Article

   


Authors: Quinn, B.; Dauer, Z.; Pandit-Taskar, N.; Schoder, H.; Dauer, L. T.
Article Title: Radiation dosimetry of 18F-FDG PET/CT: Incorporating exam-specific parameters in dose estimates
Abstract: Background: Whole body fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) is the standard of care in oncologic diagnosis and staging, and patient radiation dose must be well understood to balance exam benefits with the risk from radiation exposure. Although reference PET/CT patient doses are available, the potential for widely varying total dose prompts evaluation of clinic-specific patient dose. The aims of this study were to use exam-specific information to characterize the radiation dosimetry of PET/CT exams that used two different CT techniques for adult oncology patients and evaluate the practicality of employing an exam-specific approach to dose estimation. Methods: Whole body PET/CT scans from two sets of consecutive adult patients were retrospectively reviewed. One set received a PET scan with a standard registration CT and the other a PET scan with a diagnostic quality CT. PET dose was calculated by modifying the standard reference phantoms in OLINDA/EXM 1.1 with patient-specific organ mass. CT dose was calculated using patient-specific data in ImPACT. International Commission on Radiological Protection publication 103 tissue weighting coefficients were used for effective dose. Results: One hundred eighty three adult scans were evaluated (95 men, 88 women). The mean patient-specific effective dose from a mean injected 18F-FDG activity of 450 ± 32 MBq was 9.0 ± 1.6 mSv. For all standard PET/CT patients, mean effective mAs was 39 ± 11 mAs, mean CT effective dose was 5.0 ± 1.0 mSv and mean total effective dose was 14 ± 1.3 mSv. For all diagnostic PET/CT patients, mean effective mAs was 120 ± 51 mAs, mean CT effective dose was 15.4 ± 5.0 mSv and mean total effective dose was 24.4 ± 4.3 mSv. The five organs receiving the highest organ equivalent doses in all exams were bladder, heart, brain, liver and lungs. Conclusions: Patient-specific parameters optimize the patient dosimetry utilized in the medical justification of whole body PET/CT referrals and optimization of PET and CT acquisition parameters. Incorporating patient-specific data into dose estimates is a worthwhile effort for characterizing patient dose, and the specific dosimetric information assists in the justification of risk and optimization of PET/CT. © 2016 The Author(s).
Keywords: radiation exposure; ct; pet/ct; effective dose; 18f-fdg
Journal Title: BMC Medical Imaging
Volume: 16
ISSN: 1471-2342
Publisher: Biomed Central Ltd  
Date Published: 2016-01-18
Start Page: 41
Language: English
DOI: 10.1186/s12880-016-0143-y
PROVIDER: scopus
PMCID: PMC4912712
PUBMED: 27317478
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975256306&partnerID=40&md5=53fefcd732847822e9e13ccdc683bc04
Notes: Article -- Export Date: 1 July 2016 -- Source: Scopus
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MSK Authors
  1. Heiko Schoder
    542 Schoder
  2. Neeta Pandit-Taskar
    342 Pandit-Taskar
  3. Lawrence Dauer
    170 Dauer
  4. Brian Quinn
    20 Quinn
  5. Zachary Lawrence Dauer
    2 Dauer
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