Genome-wide techniques for the study of clinical epigenetic biomarkers Book Section

  


Authors: Toska, E.; Sanz, F. J. C.
Editor: García-Giménez, J. L.
Article/Chapter Title: Genome-wide techniques for the study of clinical epigenetic biomarkers
Abstract: Epigenetic research has gained prominence in the last decades as it provides new insights in explaining gene regulation in the context of human disease, as well as it endows with new diagnostic and prognostic tools. The identification of epigenetic biomarkers is providing with reliable indicators useful for diagnosis, prognosis, and prediction of response to therapies, thus contributing to accelerate clinical research and achieve more precise therapeutic regimes. This chapter reviews the first attempts to approach epigenetic changes and describes the latest technologies that are contributing to our knowledge of the diverse epigenomic makeup of human cells, including the latest assays to profile oxidative derivatives of 5-methylcytosine and the most recent sequencing platforms. © 2016 Elsevier Inc. All rights reserved.
Keywords: biomarkers; epigenetics; 5-methylcytosine; 5-hydroxymethylcytosine; next-generation sequencing; chip-sequencing; dna methylation array
Book Title: Epigenetic Biomarkers and Diagnostics
ISBN: 978-0-12-801899-6
Publisher: Elsevier Inc.  
Publication Place: London, United Kingdom
Date Published: 2016-01-01
Start Page: 119
End Page: 135
Language: English
DOI: 10.1016/b978-0-12-801899-6.00006-1
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018803294&doi=10.1016%2fB978-0-12-801899-6.00006-1&partnerID=40&md5=552fdef5f0e76ba9aaddffcffe872514
Notes: Book Chapter: 6 -- Export Date: 2 June 2017 -- Source: Scopus
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  1. Eneda Toska
    30 Toska
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