Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts Journal Article

  

Authors:	O'Reilly, R. J.; Small, T. N.; Papadopoulos, E.; Lucas, K.; Lacerda, J.; Koulova, L.
Article Title:	Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts
Abstract:	Epstein-Barr virus (EBV) is an ubiquitous herpesvirus which is carried as a latent infection of B lymphocytes and salivary gland epithelial cells in over 90% of normal adults. Latently infected EBV-transformed B cells circulate at low frequency in the blood for the life of the host. These transformed B cells stimulate a heterogeneous and complex host cell response, ultimately leading to the development and maintenance of high frequencies of HLA-restricted T cells specific for the EBV-encoded nuclear antigens EBNA2-EBNA6 and the latency membrane proteins LMP-1 and LMP-2. Responses to latent EBV-encoded proteins are hierarchical with responses to certain epitopes predominating, dependent upon the HLA genotype of the host. Profound suppression of T-cell immunity may permit the emergence of polyclonal, oligoclonal or monoclonal EBV antigen-expressing lymphoproliferative disorders or malignant B-cell lymphomas expressing these latent EBV antigens. Adoptive transfer of small numbers of peripheral blood mononuclear cells or HLA-partially marched T cells from in vitro expanded EBV-specific T-cell lines derived from a seropositive marrow donor has induced durable regressions of bulky, widely metastatic monoclonal EBV lymphomas in a high proportion of cases. This review describes the current state of knowledge and hypothesis regarding the biology and immunology of EBV infection in the normal host, the features of donor, host and virus which contribute to the development of EBV-associated lymphoproliferative diseases and the mechanisms whereby they are controlled by adoptive transfer of immune T cells.
Keywords:	transplantation, homologous; clinical trial; review; nonhuman; antineoplastic agent; t lymphocyte; interleukin 2; genotype; b lymphocyte; b cell lymphoma; hla matching; cellular immunity; immune response; mononuclear cell; epitope; membrane protein; epithelium cell; virus antigen; immunomodulation; salivary gland; antivirus agent; lymphoproliferative disease; bone marrow transplantation; host cell; adoptive immunotherapy; immunotherapy, adoptive; epstein barr virus; herpesvirus 4, human; lymphoproliferative disorders; lymphocyte transformation; cell nucleus antigen; latent virus infection; humans; human; priority journal
Journal Title:	Immunological Reviews
Volume:	157
Issue:	1
ISSN:	0105-2896
Publisher:	Wiley Blackwell
Date Published:	1997-06-01
Start Page:	195
End Page:	216
Language:	English
DOI:	10.1111/j.1600-065X.1997.tb00983.x
PUBMED:	9255631
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030873733&doi=10.1111%2fj.1600-065X.1997.tb00983.x&partnerID=40&md5=c76cbe11c6d3c87db61e4afa193862ef
Notes:	Review -- Export Date: 17 March 2017 -- Source: Scopus

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