Sentinel lymph node evaluation in melanoma Journal Article


Authors: Brady, M. S.; Coit, D. G.
Article Title: Sentinel lymph node evaluation in melanoma
Abstract: The surgical treatment of patients with cutaneous melanoma has been revolutionized by the development of lymphatic mapping and sentinel lymph node biopsy. This procedure involves injecting a radioactive tracer at the site of the primary melanoma (before wide excision); the tracer then travels via the lymphatics to the first draining or sentinel lymph node. The node is removed and evaluated for the presence of metastatic melanoma. In this way, patients who are most likely to benefit can be selected for regional lymphadenectomy. In addition, accurate and minimally invasive staging allows the surgeon to identify patients who may benefit from adjuvant and investigational immunotherapy. We review the development of lymphatic mapping, the technical details related to the procedure itself, and the published clinical studies using this new procedure. In addition, we discuss the controversial issues that have been raised with the introduction of sentinel lymph node biopsy.
Keywords: excision; clinical trial; review; patient selection; lymph node metastasis; lymph nodes; lymphatic metastasis; lymphoscintigraphy; intraoperative care; lymphadenectomy; melanoma; skin neoplasms; biopsy; dextran; immunotherapy; lymph node biopsy; intradermal drug administration; technetium sulfur colloid tc 99m; humans; human; priority journal
Journal Title: Archives of Dermatology
Volume: 133
Issue: 8
ISSN: 0003-987X
Publisher: American Medical Association  
Date Published: 1997-08-01
Start Page: 1014
End Page: 1020
Language: English
PUBMED: 9267249
PROVIDER: scopus
DOI: 10.1001/archderm.1997.03890440096014
DOI/URL:
Notes: Review -- Export Date: 17 March 2017 -- Source: Scopus
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  1. Mary Sue Brady
    203 Brady
  2. Daniel Coit
    542 Coit