Prognostic value of lymph node yield during nephroureterectomy for upper tract urothelial carcinoma Journal Article


Authors: Winer, A. G.; Vertosick, E. A.; Ghanaat, M.; Corradi, R. B.; Carlsson, S.; Sjoberg, D. D.; Sankin, A. I.; Sfakianos, J. P.; Cha, E. K.; Dalbagni, G.; Coleman, J. A.
Article Title: Prognostic value of lymph node yield during nephroureterectomy for upper tract urothelial carcinoma
Abstract: Introduction Lymph node dissection (LND) performed during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) remains controversial and difficult to evaluate. The aim of this study was to investigate whether removal of more lymph nodes during RNU is safe and improves oncologic outcomes. Methods We evaluated 422 patients who underwent RNU with concomitant LND for upper tract urothelial carcinoma between 1976 and 2015, assessing for an association between total nodes removed, recurrence-free survival, and cancer-specific survival using Cox proportional hazards models. We also investigated the relationship between nodal yield and perioperative metrics and intersurgeon variability using linear regression. Results In our cohort of 442 patients, 239 developed recurrences and 94 patients died of disease. Median follow-up among survivors was 3.7 years (interquartile range: 1.2, 7.4). The median nodal yield was 9 (interquartile range: 4, 16). Among patients with node-positive disease (pN1), we observed a significant improvement in recurrence-free survival (hazard ratio = 0.84 per 5 nodes removed, P = 0.039) and a nonsignificant improvement in cancer-specific survival with an increase in the nodal yield (hazard ratio = 0.90 per 5 nodes removed, P = 0.2). There was no evidence of an association between node yield and operative time, estimated blood loss, or 30-day complications on multivariable analysis. There was significant heterogeneity among surgeons regarding the extent of LND (P<0.0001). Conclusions We found that a more extensive node dissection may improve oncologic outcomes in a subset of high-risk patients without significantly increasing operative time or serious complications. Additionally, we identified considerable intersurgeon heterogeneity regarding the extent of LND furthering the notion of surgeon variability as a nonstandardized factor. © 2017 Elsevier Inc.
Keywords: complications; upper tract urothelial carcinoma; oncologic outcomes; extent of lymph node dissection; utuc
Journal Title: Urologic Oncology: Seminars and Original Investigations
Volume: 35
Issue: 4
ISSN: 1078-1439
Publisher: Elsevier Inc.  
Date Published: 2017-04-01
Start Page: 151.e9
End Page: 151.e15
Language: English
DOI: 10.1016/j.urolonc.2016.11.002
PROVIDER: scopus
PUBMED: 27932270
PMCID: PMC5502780
DOI/URL:
Notes: Article -- Export Date: 2 May 2017 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Jonathan Coleman
    193 Coleman
  2. Guido Dalbagni
    256 Dalbagni
  3. Daniel D. Sjoberg
    141 Sjoberg
  4. Eugene K. Cha
    59 Cha
  5. Mazyar   Ghanaat
    10 Ghanaat