Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries Journal Article


Authors: Begg, C. B.; Rice, M. S.; Zabor, E. C.; Tworoger, S. S.
Article Title: Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries
Abstract: Background:The somatic molecular profiles of basal-like breast cancers and high-grade serous ovarian cancers share many similarities, leading to the hypothesis that they have similar aetiologies, in which case they should occur together in the same patient more often than expected.Methods:We identified 545 women with double independent primary cancers of the breast and ovary reported to the California Cancer Registry from 1999 to 2013 and examined the coincidence of subtype combinations.Results:For most subtype combinations the observed frequencies were similar to their expected frequencies, but in 103 observed cases vs 43.8 expected (O/E=2.35; 95% CI 1.90-2.81) a triple-negative breast tumour (typically basal-like) was matched with a serous ovarian tumour (typically high-grade).Conclusions:The results provide compelling evidence that basal-like breast cancer and high-grade serous ovarian cancer share a much more similar aetiology than breast and ovarian cancers more broadly. Further research is needed to clarify the influence of germ-line BRCA1 mutations and other risk factors on these results. © 2017 Cancer Research UK. All rights reserved.
Journal Title: British Journal of Cancer
Volume: 116
Issue: 8
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2017-04-11
Start Page: 1088
End Page: 1091
Language: English
DOI: 10.1038/bjc.2017.73
PROVIDER: scopus
PUBMED: 28334730
PMCID: PMC5396122
DOI/URL:
Notes: Article -- Export Date: 2 May 2017 -- Source: Scopus
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MSK Authors
  1. Colin B Begg
    239 Begg
  2. Emily Craig Zabor
    131 Zabor