Breast cancer heterogeneity: Roles in tumorigenesis and therapeutic implications Journal Article

  


Authors: Pareja, F.; Marchiò, C.; Geyer, F. C.; Weigelt, B.; Reis-Filho, J. S.
Article Title: Breast cancer heterogeneity: Roles in tumorigenesis and therapeutic implications
Abstract: Purpose of review: Breast cancer heterogeneity constitutes a significant investigational and therapeutic challenge. Here we review recent findings on breast cancer heterogeneity, focusing on its extent across the distinct molecular subtypes, the degree of spatial and temporal intra-tumor heterogeneity, and possible approaches to dissect and counteract it. Recent findings: Recent massively parallel sequencing studies have solidified the notion that estrogen receptor (ER)-positive and ER-negative breast cancers have divergent genetic landscapes. Numerous studies have addressed the origins of heterogeneity and the challenges it poses for patient management; however, its dynamic evolution in the light of novel targeted therapies is yet to be fully understood. Summary: Tumor heterogeneity poses diagnostic and therapeutic challenges. Implementation of novel methodologies, such as single cell sequencing and analysis of cell-free DNA, might afford us the means to comprehend intra-tumor heterogeneity with greater precision, and to overcome the diagnostic and therapeutic challenges posed by it. © 2017, Springer Science+Business Media New York.
Keywords: breast cancer; estrogen receptor; heterogeneity; molecular subtypes; therapeutic implications
Journal Title: Current Breast Cancer Reports
Volume: 9
Issue: 1
ISSN: 1943-4588
Publisher: Springer  
Date Published: 2017-03-01
Start Page: 34
End Page: 44
Language: English
DOI: 10.1007/s12609-017-0233-z
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85012239704&doi=10.1007%2fs12609-017-0233-z&partnerID=40&md5=437a18d46c152f3407cb2f3536fa0b0a
Notes: Review -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Britta Weigelt
    633 Weigelt
  2. Jorge Sergio Reis-Filho
    639 Reis-Filho
  3. Fresia Gilda Pareja Zea
    217 Pareja Zea
  4. Felipe Correa Geyer
    108 Correa Geyer
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