ARF confers a context-dependent response to chemotherapy in muscle-invasive bladder cancer Journal Article
| Authors: | Owczarek, T. B.; Kobayashi, T.; Ramirez, R.; Rong, L.; Puzio-Kuter, A. M.; Iyer, G.; Teo, M. Y.; Sanchez-Vega, F.; Wang, J.; Schultz, N.; Zheng, T.; Solit, D. B.; Al-Ahmadie, H. A.; Abate-Shen, C. |
| Article Title: | ARF confers a context-dependent response to chemotherapy in muscle-invasive bladder cancer |
| Abstract: | Muscle-invasive bladder cancer (MIBC) generally responds poorly to treatment and tends to exhibit significant mortality. Here we show that expression of the tumor suppressor p14ARF (ARF) is upregulated in aggressive subtypes of MIBC. Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated response to chemotherapy. In both genetically engineered mouse models and murine xenograft models of human MIBC, we demonstrate that tumors expressing ARF failed to respond to treatment with the platinumbased chemotherapy agent cisplatin. Resistance was mediated in part by the integrin-binding protein ITGB3BP (CENPR) and reflected ARF-dependent impairment of protein translation, which was exaggerated by drug treatment. Overall, our results highlight a context-dependent role for ARF in modulating the drug response of bladder cancer. © 2017 American Association for Cancer Research. |
| Journal Title: | Cancer Research |
| Volume: | 77 |
| Issue: | 4 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2017-02-01 |
| Start Page: | 1035 |
| End Page: | 1046 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-16-2621 |
| PROVIDER: | scopus |
| PMCID: | PMC5313321 |
| PUBMED: | 28082400 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 April 2017 -- Source: Scopus |
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780Solit -
348Iyer -
661Al-Ahmadie -
488Schultz -
19Ramirez -
105Teo -
137Sanchez Vega
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