p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development Journal Article

  


Authors: Carneiro, C.; Jiao, M. S.; Hu, M.; Shaffer, D.; Park, M.; Pandolfi, P. P.; Cordon-Cardo, C.; Koff, A.
Article Title: p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development
Abstract: Low p27 expression in many human cancers is a prognostic indicator for poor outcome. While analysing the mechanism by which p27 deficiency contributed to tumor development in the Rb+/- mouse model, we identified a role for p27 as a proapoptotic tumor suppressor. We examined the cell cycle and apoptotic response of these pituitary tumor cells to the dopamine analog bromocriptine as well as the expression of Arf and other cell cycle and apoptotic regulators in these tumors. We also examined the expression of Arf and its function in mouse embryo fibroblasts either singly or doubly deficient for Rb and p27. From these studies, we concluded that the absence of p27 disabled the trigger for an Arf-dependent apoptotic response in Rb-/- tumor cells. This suggests a novel mechanism by which the loss of p27 may impact on tumor development.
Keywords: signal transduction; protein expression; nonhuman; protein function; animal cell; mouse; animals; cell cycle proteins; mice; cell cycle; cell division; apoptosis; embryo; animal experiment; animal model; mice, mutant strains; animalia; tumorigenesis; tumor suppressor gene; protein p27; cyclin-dependent kinase inhibitor p27; tumor suppressor proteins; tumor cell; fibroblast; fibroblasts; protein deficiency; arf protein; cyclin-dependent kinase inhibitor p16; tumor suppressor protein p14arf; tumor growth; retinoblastoma protein; dopamine; rb; p27kip1; hypophysis tumor; bromocriptine; pituitary gland; pituitary neoplasms; arf; priority journal; article; dopamine agonists
Journal Title: Oncogene
Volume: 22
Issue: 3
ISSN: 0950-9232
Publisher: Nature Publishing Group  
Date Published: 2003-01-23
Start Page: 361
End Page: 369
Language: English
DOI: 10.1038/sj.onc.1206163
PUBMED: 12545157
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0037461916&partnerID=40&md5=47ed6c22c0d2329952dfa757b8706532
Notes: Export Date: 12 September 2014 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Andrew C Koff
    110 Koff
  2. Carmen Carneiro
    2 Carneiro
  3. Pier Paolo Pandolfi Derinaldis
    353 Pandolfi Derinaldis
  4. Carlos Cordon-Cardo
    612 Cordon-Cardo
  5. Ming Hu
    2 Hu
  6. David R Shaffer
    25 Shaffer
  7. Maria Socorro Frankowski
    3 Frankowski
Related MSK Work