Prognostic significance of detection of prostate-specific antigen transcripts in the peripheral blood of patients with metastatic androgen-independent prostatic carcinoma Journal Article

  

Authors:	Ghossein, R. A.; Rosai, J.; Scher, H. I.; Seiden, M.; Zhang, Z. F.; Sun, M.; Chang, G.; Berlane, K.; Krithivas, K.; Kantoff, P. W.
Article Title:	Prognostic significance of detection of prostate-specific antigen transcripts in the peripheral blood of patients with metastatic androgen-independent prostatic carcinoma
Abstract:	Objectives. To evaluate the prognostic significance of reverse transcriptase polymerase chain reaction (RT PCR) detection of prostate- specific antigen (PSA) mRNA in relation to survival in patients with metastatic androgen-independent prostatic carcinoma (AIPC). Methods. Peripheral blood from 122 men (64 from Memorial Sloan-Kettering Cancer Center [MSKCC] and 58 from the Dana Farber Cancer Institute [DFCI] with metastatic (Stage D2) AIPC was analyzed for PSA mRNA using RT PCR. Forty-one controls without prostatic carcinoma were also evaluated. Results. RT PCR positivity for PSA mRNA was present in 24 of the 64 (38%) patients seen at MSKCC and in 26 of the 58 (45%) patients followed at DFCI. All control individuals were PSA PCR negative. There was a significant correlation between RT PCR positivity and decreased survival in each of the Memorial and Dana Farber populations (P = 0.028 and 0.039, respectively). Serum PSA (at time of blood collection for PCR) was not predictive of survival as a continuous variable in the MSKCC (P = 0.31) and the DFCI (P = 0.09) groups. RT PCR for PSA mRNA was found to be independent from and superior to serum PSA in predicting survival in both the MSKCC and DFCI populations (P = 0.048 and P = 0.027, respectively). Conclusions. The detection of PSA mRNA in the peripheral blood by RT PCR is a predictor of survival in patients with metastatic AIPC, and PCR is superior to a single serum PSA measurement. Further studies are needed to test the values of this factor in comparison to and coupled with other prognostic parameters.
Keywords:	adult; cancer survival; controlled study; aged; aged, 80 and over; middle aged; survival rate; major clinical study; diagnostic accuracy; polymerase chain reaction; prostate specific antigen; reverse transcription polymerase chain reaction; prostate-specific antigen; prostatic neoplasms; diagnostic value; rna, messenger; neoplasm metastasis; multivariate analysis; testosterone; prostate carcinoma; humans; prognosis; human; male; priority journal; article
Journal Title:	Urology
Volume:	50
Issue:	1
ISSN:	0090-4295
Publisher:	Elsevier Science, Inc.
Date Published:	1997-07-01
Start Page:	100
End Page:	105
Language:	English
DOI:	10.1016/s0090-4295(97)00127-1
PUBMED:	9218026
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-17444434615&doi=10.1016%2fS0090-4295%2897%2900127-1&partnerID=40&md5=a740fc746aa2107fcabd4953090d7629
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/108272