Applications of brachytherapy in head and neck cancer Journal Article


Author: Harrison, L. B.
Article Title: Applications of brachytherapy in head and neck cancer
Abstract: Brachytherapy offers the radiation oncologist the opportunity to deliver high doses of radiation to the tumor, with minimal doses to the surrounding normal tissue. This combination enhances the therapeutic ratio. It allows for enhanced tumor control, with minimal toxicity. When utilized, it often allows for tumor control without the need for resection. This is especially important in the head and neck. Resection of organs such as the lip, oral tongue, base-of-tongue, and other sites can cause significant functional and cosmetic morbidity. The ability to save these structures, using radiation therapy instead of surgery, can provide excellent tumor control and optimal quality-of-life outcome. In situations of recurrent disease, especially when prior radiation has been given, brachytherapy is often the only way to re- irradiate certain areas. This can be done alone, or in combination with surgery. Therefore, brachytherapy becomes an important component of the treatment of recurrent disease. This broad overview of the use of brachytherapy in head and neck cancer will include applications in the primary as well as the recurrent disease setting.
Keywords: survival rate; cancer recurrence; head and neck surgery; squamous cell carcinoma; carcinoma, squamous cell; quality of life; neoplasm recurrence, local; dose-response relationship, radiation; radiation dosage; iodine 125; head and neck cancer; head and neck neoplasms; brachytherapy; nasopharyngeal neoplasms; radioisotopes; tongue neoplasms; mouth neoplasms; iridium 192; humans; prognosis; human; priority journal; article; lip neoplasms
Journal Title: Seminars in Surgical Oncology
Volume: 13
Issue: 3
ISSN: 8756-0437
Publisher: John Wiley & Sons  
Date Published: 1997-05-01
Start Page: 177
End Page: 184
Language: English
DOI: 10.1002/(sici)1098-2388(199705/06)13:3<177::aid-ssu4>3.0.co;2-4
PUBMED: 9143055
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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  1. Louis B Harrison
    123 Harrison