Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx Journal Article
| Authors: | Kraus, D. H.; Zelefsky, M. J.; Brock, H. A. J.; Huo, J.; Harrison, L. B.; Shah, J. P. |
| Article Title: | Combined surgery and radiation therapy for squamous cell carcinoma of the hypopharynx |
| Abstract: | Squamous cell carcinoma of the hypopharynx remains a highly lethal disease. This article documents our experience with 132 patients undergoing surgical management of squamous cell carcinoma of the hypopharynx, of whom 80% received postoperative radiation therapy. Local-regional control was obtained in 61% of the patients. Five-year overall and disease-free survival rates were 30% and 41%, respectively. Prognosis was better in patients with limited disease: local disease permitting larynx-sparing surgery, N0/N1 clinical neck, and stage I/II/III disease. Cancer of the hypopharynx remains an aggressive entity associated with poor prognosis. Novel strategies stressing improved local-regional control with prevention of distant metastasis are warranted. |
| Keywords: | adult; human tissue; aged; disease-free survival; middle aged; survival rate; retrospective studies; major clinical study; laryngectomy; squamous cell carcinoma; carcinoma, squamous cell; cancer radiotherapy; radiotherapy, adjuvant; cancer staging; neoplasm staging; metastasis; radiotherapy dosage; ear nose throat surgery; hypopharynx carcinoma; hypopharyngeal neoplasms; humans; prognosis; human; male; female; article |
| Journal Title: | Otolaryngology - Head and Neck Surgery |
| Volume: | 116 |
| Issue: | 6 |
| ISSN: | 0194-5998 |
| Publisher: | Sage Publications |
| Date Published: | 1997-06-01 |
| Start Page: | 637 |
| End Page: | 641 |
| Language: | English |
| DOI: | 10.1016/s0194-5998(97)70240-7 |
| PUBMED: | 9215375 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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