Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium-choline Journal Article
| Authors: | Street, J. C.; Szwergold, B. S.; Matei, C.; Kappler, F.; Mahmood, U.; Brown, T. R.; Koutcher, J. A. |
| Article Title: | Study of the metabolism of choline and phosphatidylcholine in tumors in vivo using phosphonium-choline |
| Abstract: | The results of an initial study on the feasibility of using the phosphonium analog of choline to follow the metabolism of phosphatidylcholine in tumors in vivo using 31P NMR are reported. C3H/He mice bearing a mammary carcinoma tumor on the foot pad were fed a choline-free diet supplemented with the phosphonium analog of choline. Metabolites of this compound, including the phosphonium analogs of phosphatidylcholine, phosphocholine, glycerophosphocholine, and betaine were observed noninvasively in vivo in tumors by 31P NMR after 2-3 weeks of feeding. Clearance of these phosphonium-labeled metabolites from tumors was measured after a change to a choline-containing diet. Significant decreases were seen in the levels of the analogs of betaine (P < 0.003) and phosphatidylcholine (P < 0.004) by Day 4. A significant increase in the level of authentic phosphocholine (P < 0.003) occurred over the same time period. |
| Keywords: | nonhuman; adenocarcinoma; mouse; animals; mice; animal experiment; animal model; diet supplementation; statistical analysis; breast carcinoma; foot pad; magnetic resonance spectroscopy; choline; tumor growth; lipid metabolism; phosphorus nuclear magnetic resonance; phosphatidylcholine; mammary neoplasms, experimental; organophosphorus compounds; mice, inbred c3h; cancer graft; phosphatidylcholines; female; article; betaine derivative; phosphonium derivative |
| Journal Title: | Magnetic Resonance in Medicine |
| Volume: | 38 |
| Issue: | 5 |
| ISSN: | 0740-3194 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1997-11-01 |
| Start Page: | 769 |
| End Page: | 775 |
| Language: | English |
| DOI: | 10.1002/mrm.1910380513 |
| PUBMED: | 9358451 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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