Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids Journal Article

  


Authors: Street, J. C.; Koutcher, J. A.
Article Title: Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids
Abstract: Phospholipid extracts were made of a murine mammary adenocarcinoma implanted in the dorsum of the foot of C3H/He mice before and 96 h after 17 Gy irradiation or 150 mg/kg cyclophosphamide. Extracts of untreated tumors, which had grown for a further 96 h, were also studied. Although previous studies have shown significant changes in the precursors and catabolites of phosphatidylcholine and phosphatidylethanolamine following therapy, 31P nuclear magnetic resonance analysis of extracts showed no changes in these membrane constituents and other observed phospholipid species. A significant decrease in 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, however, was observed 96 h following cyclophosphamide treatment.
Keywords: cancer chemotherapy; controlled study; nonhuman; cancer radiotherapy; adenocarcinoma; mouse; animals; mice; animal tissue; animal experiment; animal model; cyclophosphamide; antineoplastic agents, alkylating; magnetic resonance spectroscopy; neoplasm transplantation; phosphatidylethanolamine; phosphatidylethanolamines; disease models, animal; breast adenocarcinoma; phosphorus nuclear magnetic resonance; phosphatidic acid; phosphatidylcholine; phospholipids; mice, inbred c3h; lipid composition; membrane phospholipid; membrane lipids; lysophosphatidylcholine; phosphatidylinositol; phosphatidylcholines; humans; male; article; plasmalogens
Journal Title: Lipids
Volume: 32
Issue: 1
ISSN: 0024-4201
Publisher: Springer Verlag  
Date Published: 1997-01-01
Start Page: 45
End Page: 49
Language: English
DOI: 10.1007/s11745-997-0007-2
PUBMED: 9075192
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031019628&doi=10.1007%2fs11745-997-0007-2&partnerID=40&md5=8cfa1d1bcc19b227187b6653e166ac87
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
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MSK Authors
  1. Jason A Koutcher
    278 Koutcher
  2. James C. Street
    10 Street
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