Implant brachytherapy: A novel treatment for recurrent orbital rhabdomyosarcoma Journal Article
| Authors: | Abramson, D. H.; Fass, D.; McCormick, B.; Servodidio, C. A.; Piro, J. D.; Anderson, L. L. |
| Article Title: | Implant brachytherapy: A novel treatment for recurrent orbital rhabdomyosarcoma |
| Abstract: | Background: Orbital rhabdomyosarcoma is the most common primary malignancy of the orbit in childhood. Tumor resection and exenteration were the preferred treatment modalities for rhabdomyosarcoma. In the past 20 years, however, combined local radiation and systemic chemotherapy have shown excellent survival results. Tumor recurrence after any of the aforementioned therapies is almost always fatal. We have developed a novel treatment for recurrent disease that has resulted in long-term survival for three patients. Methods: Three patients with recurrent orbital rhabdomyosarcoma were previously treated with primary radiation and chemotherapy. At the time of recurrence, exenteration and localized brachytherapy were performed. An individually molded poly(methylmethacrylate) (Lucite; E. I. du Pont de Nemours & Co., Wilmington, Del.) device loaded with radioactive iodine seeds delivered localized high-dose radiation, 6000 cGy over 6 days, to the orbit without irradiating the brain. Results: All patients are alive and free of disease with follow-up ranging from 4 years and 4 months to 8 years and 4 months. Conclusion: A novel technique of delivering localized radiation to the orbit of three children with recurrent orbital rhabdomyosarcoma appears curative. Copyright © 1997 by the American Association for Pediatric Ophthalmology and Strabismus. |
| Keywords: | child; preschool child; treatment outcome; child, preschool; survival rate; mortality; case report; nuclear magnetic resonance imaging; magnetic resonance imaging; computer assisted tomography; neoplasm recurrence, local; tomography, x-ray computed; radioactive iodine; iodine radioisotopes; tumor recurrence; brachytherapy; rhabdomyosarcoma; orbit tumor; orbital neoplasms; humans; human; male; article |
| Journal Title: | Journal of American Association for Pediatric Ophthalmology and Strabismus (AAPOS) |
| Volume: | 1 |
| Issue: | 3 |
| ISSN: | 1091-8531 |
| Publisher: | American Association for Pediatric Ophthalmology and Strabismus |
| Date Published: | 1997-09-01 |
| Start Page: | 154 |
| End Page: | 157 |
| Language: | English |
| PUBMED: | 10532778 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S1091-8531(97)90058-6 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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