Normalization of the tumor marker CA-125 after oophorectomy in a patient with paraneoplastic cerebellar degeneration without detectable cancer Journal Article
| Authors: | Mason, W. P.; Dalmau, J.; Curtin, J. P.; Posner, J. B. |
| Article Title: | Normalization of the tumor marker CA-125 after oophorectomy in a patient with paraneoplastic cerebellar degeneration without detectable cancer |
| Abstract: | A 61-year-old woman developed severe subacute cerebellar degeneration in association with a neuronal antinuclear autoantibody. Neurologic investigations were remarkable only for mild CSF leukocytosis. Despite no radiographic evidence of cancer, a salpingo-oophorectomy was performed on the basis of an increased gynecologic cancer marker (CA-125) and the neurologic symptoms that were strongly suggestive of paraneoplastic cerebellar degeneration. Although no tumor was detected in the surgical specimen, CA- 125 levels normalized after surgery. The patient remains stable 12 months after surgery with a severe cerebellar syndrome, no evidence of cancer, and persistent circulating antineuronal autoantibodies. An elevated tumor marker in a patient with a presumed paraneoplastic neurologic disorder should suffice as evidence of an occult neoplasm, and guide definitive treatment. |
| Keywords: | adult; middle aged; case report; salpingooophorectomy; ovariectomy; tumor markers, biological; tumor marker; ovary; antinuclear antibody; ca 125 antigen; ca-125 antigen; paraneoplastic syndrome; leukocytosis; autoantibodies; occult cancer; cerebellar diseases; paraneoplastic syndromes; cerebellum degeneration; humans; human; female; priority journal; article |
| Journal Title: | Gynecologic Oncology |
| Volume: | 65 |
| Issue: | 1 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-04-01 |
| Start Page: | 173 |
| End Page: | 176 |
| Language: | English |
| DOI: | 10.1006/gyno.1997.4618 |
| PUBMED: | 9103409 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
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