| Authors: |
Kar, S. P.; Beesley, J.; Al Olama, A. A.; Michailidou, K.; Tyrer, J.; Kote-Jarai, Z. A.; Lawrenson, K.; Lindstrom, S.; Ramus, S. J.; Thompson, D. J.; Kibel, A. S.; Dansonka-Mieszkowska, A.; Michael, A.; Dieffenbach, A. K.; Gentry-Maharaj, A.; Whittemore, A. S.; Wolk, A.; Monteiro, A.; Peixoto, A.; Kierzek, A.; Cox, A.; Rudolph, A.; Gonzalez-Neira, A.; Wu, A. H.; Lindblom, A.; Swerdlow, A.; Ziogas, A.; Ekici, A. B.; Burwinkel, B.; Karlan, B. Y.; Nordestgaard, B. G.; Blomqvist, C.; Phelan, C.; McLean, C.; Pearce, C. L.; Vachon, C.; Cybulski, C.; Slavov, C.; Stegmaier, C.; Maier, C.; Ambrosone, C. B.; Hogdall, C. K.; Teerlink, C. C.; Kang, D.; Tessier, D. C.; Schaid, D. J.; Stram, D. O.; Cramer, D. W.; Neal, D. E.; Eccles, D.; Flesch-Janys, D.; Velez Edwards, D. R.; Wokozorczyk, D.; Levine, D. A.; Yannoukakos, D.; Sawyer, E. J.; Bandera, E. V.; Poole, E. M.; Goode, E. L.; Khusnutdinova, E.; Hogdall, E.; Song, F.; Bruinsma, F.; Heitz, F.; Modugno, F.; Hamdy, F. C.; Wiklund, F.; Giles, G. G.; Olsson, H.; Wildiers, H.; Ulmer, H. U.; Pandha, H.; Risch, H. A.; Darabi, H.; Salvesen, H. B.; Nevanlinna, H.; Gronberg, H.; Brenner, H.; Brauch, H.; Anton-Culver, H.; Song, H.; Lim, H. Y.; McNeish, I.; Campbell, I.; Vergote, I.; Gronwald, J.; Lubiński, J.; Stanford, J. L.; Benitez, J.; Doherty, J. A.; Permuth, J. B.; Chang-Claude, J.; Donovan, J. L.; Dennis, J.; Schildkraut, J. M.; Schleutker, J.; Hopper, J. L.; Kupryjanczyk, J.; Park, J. Y.; Figueroa, J.; Clements, J. A.; Knight, J. A.; Peto, J.; Cunningham, J. M.; Pow-Sang, J.; Batra, J.; Czene, K.; Lu, K. H.; Herkommer, K.; Khaw, K. T.; Matsuo, K.; Muir, K.; Offitt, K.; Chen, K.; Moysich, K. B.; Aittomaki, K.; Odunsi, K.; Kiemeney, L. A.; Massuger, L. F. A. G.; Fitzgerald, L. M.; Cook, L. S.; Cannon-Albright, L.; Hooning, M. J.; Pike, M. C.; Bolla, M. K.; Luedeke, M.; Teixeira, M. R.; Goodman, M. T.; Schmidt, M. K.; Riggan, M.; Aly, M.; Rossing, M. A.; Beckmann, M. W.; Moisse, M.; Sanderson, M.; Southey, M. C.; Jones, M.; Lush, M.; Hildebrandt, M. A. T.; Hou, M. F.; Schoemaker, M. J.; Garcia-Closas, M.; Bogdanova, N.; Rahman, N.; Le, N. D.; Orr, N.; Wentzensen, N.; Pashayan, N.; Peterlongo, P.; Guenel, P.; Brennan, P.; Paulo, P.; Webb, P. M.; Broberg, P.; Fasching, P. A.; Devilee, P.; Wang, Q.; Cai, Q.; Li, Q.; Kaneva, R.; Butzow, R.; Kopperud, R. K.; Schmutzler, R. K.; Stephenson, R. A.; Macinnis, R. J.; Hoover, R. N.; Winqvist, R.; Ness, R.; Milne, R. L.; Travis, R. C.; Benlloch, S.; Olson, S. H.; McDonnell, S. K.; Tworoger, S. S.; Maia, S.; Berndt, S.; Lee, S. C.; Teo, S. H.; Thibodeau, S. N.; Bojesen, S. E.; Gapstur, S. M.; Kjar, S. K.; Pejovic, T.; Tammela, T. L. J.; Eeles, A.; Easton, D.; Kote-Jarai, Z. S.; Al Olama, A. A.; Benlloch, S.; Muir, K.; Giles, G. G.; Southey, M. C.; Fitzgerald, L. M.; Gronberg, H.; Wiklund, F.; Aly, M.; Henderson, B. E.; Schumacher, F.; Haiman, C. A.; Schleutker, J.; Wahlfors, T.; Tammela, T. L. J.; Nordestgaard, B. G.; Key, T. J.; Travis, R. C.; Neal, D. E.; Donovan, J. L.; Hamdy, F. C.; Pharoah, P.; Pashayan, N.; Khaw, K. T.; Stanford, J. L.; Thibodeau, S. N.; McDonnell, S. K.; Schaid, D. J.; Maier, C.; Vogel, W.; Luedeke, M.; Herkommer, K.; Kibel, A. S.; Cybulski, C.; Wokozorczyk, D.; Kluzniak, W.; Cannon-Albright, L.; Brenner, H.; Dieffenbach, A. K.; Arndt, V.; Park, J. Y.; Sellers, T.; Lim, H. Y.; Slavov, C.; Kaneva, R.; Mitev, V.; Batra, J.; Spurdle, A.; Teixeira, M. R.; Paulo, P.; Maia, S.; Pandha, H.; Michael, A.; Kierzek, A.; Dork, T.; Bruning, T.; Wahlfors, T.; Key, T. J.; Edwards, T. L.; Menon, U.; Hamann, U.; Mitev, V.; Kosma, V. M.; Setiawan, V. W.; Kristensen, V.; Arndt, V.; Vogel, W.; Zheng, W.; Sieh, W.; Blot, W. J.; Kluzniak, W.; Shu, X. O.; Gao, Y. T.; Schumacher, F.; Freedman, M. L.; Berchuck, A.; Dunning, A. M.; Simard, J.; Haiman, C. A.; Spurdle, A.; Sellers, T. A.; Hunter, D. J.; Henderson, B. E.; Kraft, P.; Chanock, S. J.; Couch, F. J.; Hall, P.; Gayther, S. A.; Easton, D. F.; Chenevix-Trench, G.; Eeles, R.; Pharoah, P. D. P.; Lambrechts, D. |
| Article Title: |
Genome-wide meta-analyses of Breast, Ovarian, and Prostate Cancer Association Studies identify multiple new susceptibility loci shared by at least two cancer types |
| Abstract: |
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/ BCL2L11; rs7937840/11q12/ INCENP; rs1469713/19p13/ GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/ SMC2; rs8037137/15q26/ RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/ NSUN4; rs9375701/6q23/ L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10−5 in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. © 2016 American Association for Cancer Research. |
| Journal Title: |
Cancer Discovery
|
| Volume: |
6 |
| Issue: |
9 |
| ISSN: |
2159-8274 |
| Publisher: |
American Association for Cancer Research
|
| Date Published: |
2016-09-01 |
| Start Page: |
1052 |
| End Page: |
1067 |
| Language: |
English |
| DOI: |
10.1158/2159-8290.cd-15-1227
|
| PROVIDER: |
scopus
|
| PMCID: |
PMC5010513
|
| PUBMED: |
27432226
|
| DOI/URL: |
|
| Notes: |
Article -- Export Date: 2 March 2017 -- Source: Scopus |
