Involvement of interleukin-3 in delayed-type hypersensitivity Journal Article
| Authors: | Mach, N.; Lantz, C. S.; Galli, S. J.; Reznikoff, G.; Mihm, M.; Small, C.; Granstein, R.; Beissert, S.; Sadelain, M.; Mulligan, R. C.; Dranoff, G. |
| Article Title: | Involvement of interleukin-3 in delayed-type hypersensitivity |
| Abstract: | The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity. (C) 1998 by The American Society of Hematology. |
| Keywords: | mice; gene; tumor-necrosis-factor; colony-stimulating factor; lines; langerhans cells; hematopoietic progenitor cells; invivo; contact hypersensitivity; multi-csf il-3 |
| Journal Title: | Blood |
| Volume: | 91 |
| Issue: | 3 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 1998-02-01 |
| Start Page: | 778 |
| End Page: | 783 |
| Language: | English |
| ACCESSION: | WOS:000071644000007 |
| PROVIDER: | wos |
| PUBMED: | 9446636 |
| DOI: | 10.1182/blood.V91.3.778 |
| Notes: | Article -- Source: Wos |
