Fyn, a Src family tyrosine kinase Journal Article
| Author: | Resh, M. D. |
| Article Title: | Fyn, a Src family tyrosine kinase |
| Abstract: | Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like membrane microdomains, and can interact with a variety of other signaling molecules. Fyn's biological functions are diverse, and include signaling via the T cell receptor, regulation of brain function, as well as adhesion mediated signaling. Alteration of the levels of Fyn in appropriate target tissues may lead to better treatments for alcoholism and autoimmune disease. Copyright (C) 1998 Elsevier Science Ltd. |
| Keywords: | signal transduction; proto-oncogene proteins; mitosis; t-lymphocytes; animals; mice; protein targeting; protein tyrosine kinase; oncogene; t lymphocyte receptor; brain; protein synthesis; cell membrane; polysome; short survey; binding sites; autoimmune diseases; enzyme structure; cell adhesion; brain function; protein modification; mitogens; palmitoylation; proto-oncogene proteins c-fyn; myristylation; oncogene src; humans; oncogene fyn |
| Journal Title: | International Journal of Biochemistry and Cell Biology |
| Volume: | 30 |
| Issue: | 11 |
| ISSN: | 1357-2725 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-11-01 |
| Start Page: | 1159 |
| End Page: | 1162 |
| Language: | English |
| DOI: | 10.1016/s1357-2725(98)00089-2 |
| PUBMED: | 9839441 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Short Survey -- Export Date: 12 December 2016 -- Source: Scopus |
