A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth Journal Article


Authors: Wary, K. K.; Mariotti, A.; Zurzolo, C.; Giancotti, F. G.
Article Title: A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
Abstract: Caveolin-1 functions as a membrane adaptor to link the integrin α subunit to the tyrosine kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc. Shc is subsequently phosphorylated at tyrosine 317 and recruits Grb2. This sequence of events is necessary to couple integrins to the Ras-ERK pathway and promote cell cycle progression. These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth.
Keywords: signal transduction; proto-oncogene proteins; nonhuman; protein domain; proteins; animal cell; animals; mice; cells, cultured; cell cycle; cell division; cell growth; protein binding; membrane proteins; animalia; amino acid sequence; adaptor proteins, signal transducing; cell fractionation; rats; protein-tyrosine kinases; ras proteins; thyroid gland; mitogen-activated protein kinases; protein kinase; integrin; integrins; 3t3 cells; grb2 adaptor protein; rats, inbred f344; adaptor proteins, vesicular transport; solubility; octoxynol; proto-oncogene proteins c-fyn; caveolin; caveolin 1; priority journal; article; src homology domains; caveolins
Journal Title: Cell
Volume: 94
Issue: 5
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1998-09-04
Start Page: 625
End Page: 634
Language: English
DOI: 10.1016/s0092-8674(00)81604-9
PUBMED: 9741627
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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  1. Kishore K Wary
    8 Wary